Tinnitus, Subjective

9

Review clinical trials related to Tinnitus, Subjective. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Tinnitus Patient Preferences Survey

The goal of this survey is to assess several aspects related to patient preferences regarding interventions for alleviating tinnitus through invasive electrical brain stimulation (neuromodulation). This survey covers the acceptance of a surgically-placed brain implant, of its associated risks related to the neurosurgical procedure, usability considerations, and the willingness/ability to pay for such a treatment. Neurosoft Bioelectronics will use the collected patients' feedback and usability preferences data for the development of a novel minimally invasive brain implant aimed at alleviating tinnitus.

Participants needed: 500
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Nicolas GninenkoUpdated: Apr 8, 2026Locations: 1Duration: 1 Day
Eligibility criteria

Individuals aged 18 or older suffering from subjective tinnitus [+1]

Individuals under 18 years of age [+1]

Status: Recruiting

Bimodal Electrical-Sound Stimulation and Auditory Training for Chronic Tonal Tinnitus

This study tests whether pairing non-invasive stimulation of the greater occipital nerve (NITESGON) with an attentionally demanding auditory frequency discrimination training task reduces tinnitus loudness and tinnitus-related distress. One hundred adults with chronic tonal tinnitus will be randomised to one of four groups in a 2×2 factorial design: real versus sham NITESGON and active versus passive listening during auditory stimulation. Participants complete eight sessions across four weeks, with outcomes assessed at baseline, end of treatment, 28 days post-treatment, and 6 months post-treatment.

Participants needed: 100
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: University of Dublin, Trinity CollegeUpdated: Apr 3, 2026Locations: 1
Eligibility criteria

Adults aged 18-80 years [+6]

Objective tinnitus or predominantly somatic tinnitus [+16]

Status: Not yet recruiting

Multimodal Therapy for Somatosensory Tinnitus

Tinnitus (ringing or buzzing in the ears) affects approximately 10-15% of the adult population and significantly reduces quality of life in many patients. In a substantial proportion of cases, tinnitus is associated with dysfunction of the temporomandibular joint (TMJ) and cervical spine - this subtype is called somatosensory tinnitus. This randomised controlled trial investigates the effectiveness of a multimodal intervention combining: (1) physiotherapy targeting TMJ and cervical spine dysfunction, (2) a structured combined exercise program (aerobic + resistance + breathing), and (3) psychological support (cognitive-behavioural psychoeducation) in patients with chronic somatosensory tinnitus. The study also examines the acute effects of different types and intensities of physical exercise on tinnitus perception, and performs psychometric validation of Czech-language tinnitus assessment questionnaires. Participants (N=160, aged 18-70 years) will be randomly assigned to either the multimodal intervention group (8 weeks, 5 sessions/week) or a control group. Follow-up assessments will be conducted at 3, 12, and 24 months. The primary outcome is the change in the Tinnitus Handicap Inventory (THI) score.

Participants needed: 160
Trial details
Age: 18-70Biological sex: AllType: InterventionalSponsor: Charles University, Czech RepublicUpdated: Mar 12, 2026Locations: 1
Eligibility criteria

Age 18-70 years (inclusive) [+9]

Objective or pulsatile tinnitus [+27]

Status: Recruiting

Noninvasive Therapy for Tinnitus

The goal of this interventional clinical study is to establish mild therapeutic hypothermia, delivered non-invasively to the structures of the inner ear, as a safe and repeatable therapeutic method for symptomatic relief of tinnitus. The study will assess both objective and subjective measures to address two main aims: 1. Ascertain the benefits of mild therapeutic hypothermia for symptomatic relief of chronic tinnitus in participants using the ReBound hypothermia device. 2. Ascertain the benefits of mild therapeutic hypothermia for symptom management in chronic tinnitus participants over six months using the ReBound device. Participants will wear the ReBound hypothermia device for 30 minutes in a single session. Researchers will compare results from those receiving the therapy to those from a control group (sham therapy). Participants will also use the device in-home for 6 months and monitor their symptoms with online surveys.

Participants needed: 40
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Restorear Devices LLCUpdated: Jan 12, 2026Locations: 1
Eligibility criteria

Adults aged 18 years or older at the time of signing the consent form [+3]

Severe anxiety, score ≥ 15 on the Generalized Anxiety Disorder-7 (GAD-7) [+14]

Status: Recruiting

Neuromodulatory Effects of Audio-proprio-phonatory Reinforcement Training on Subjective Tinnitus, Demonstrated by High-density Electroencephalogram (HD EEG)

Our ecological approach to neuromodulation in the field of "acouphonology" empowers tinnitus patients to act as their own source of sound stimuli through audio-proprio-phonatory reinforcement (APPR). By engaging in self-phonations, individuals uncoverthe vast potential for sound production, which can effectively mask their tinnitus or induce residual inhibition, all without relying on external sources. This clinical study aims to illustrate the positive impact of audio-proprio-phonatory reinforcement training on individuals suffering from chronic subjective tinnitus. This will be further supported and quantified through high-definition electroencephalography (HD EEG) as we explore the relationship between changes in connectivity within specific brain regions and the varying degrees of response to the therapeutic protocol.

Participants needed: 56
Trial details
Age: 18-84Biological sex: AllType: InterventionalSponsor: Centre Hospitalier Régional d'OrléansUpdated: Dec 30, 2025Locations: 1
Eligibility criteria

Person who agreed to participate in the study and gave consent [+8]

Patient suffering from objective tinnitus [+11]

Status: Recruiting

External Therapy for Tinnitus Management

The goal of this remote interventional clinical study is to investigate the use of mild therapeutic hypothermia devices for the symptomatic relief of chronic tinnitus. The main aims of the study are: 1. Ascertain the effects of MTH in chronic tinnitus patients using questionnaires measuring tinnitus severity and intervention-related change. 2. Ascertain the comfort and acceptability of the hypothermia device and therapy. Participants with chronic tinnitus will wear the mild therapeutic hypothermia therapy devices for a single 30 minute session. Researchers will compare results from those receiving therapy to those from a control group.

Participants needed: 80
Trial details
Age: 18-55Biological sex: AllType: InterventionalSponsor: Restorear Devices LLCUpdated: Sep 17, 2025Locations: 1
Eligibility criteria

Adults 18-55 years of age at the time of signing the informed consent form with... [+3]

Very mild tinnitus (THI values <12); [+7]

Status: Recruiting

Efficacy of Walking Exercise With Dog on Tinnitus Complaints in Sleep Apnea (Obstructive Sleep Apnea)

there is evidence that tinnitus (chronic subjective form) is highly prevalent among patients with obstructive sleep apnea. exercise is recommneded in chronic subjective form) and obstructive sleep apnea. walking with dog increase adherence to walking to maintain continuity of physical activity

Participants needed: 40
Trial details
Age: 30-45Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Jan 31, 2025Locations: 1
Eligibility criteria

obese persons [+3]

body mass index more than 40 kg/m2. [+4]

Status: Not yet recruiting

Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus

This clinical study is a prospective, multicenter, randomized, controlled, double-blind clinical study. Sun Yat Sen Memorial Hospital of Sun Yat sen University was the central unit, and Nanjing First Hospital, Sun Yat Sen people's Hospital, Guanfzhou Panyu central Hospital and Zhuhai integrated traditional Chinese and Western medicine hospital were the cooperative units. In this study, 388 patients with chronic subjective tinnitus were recruited. In view of chronic subjective tinnitus, a common ear disease, the study gave the patients three months of treatment with transcutaneous vagus nerve stimulation paired with tailor-made notched music therapy or tailor-made notched music training alone. By comparing the changes of subjective scale scores related to tinnitus before and after treatment in patients receiving two different therapies, such as THI, VAS, BAI, BDI, PSQI, to evaluate the efficacy of the two therapies, so as to judge whether transcutaneous vagus nerve stimulation paired with tailor-made notched music therapy is better than tailor-made notched music training alone. In addition, the study will continue to follow up the patients after the treatment for one year to observe the difference in the long-term sustained efficacy of the two therapies. This clinical study will also evaluate the two therapies from the perspective of compliance and safety, and explore the factors that affect the efficacy of the two therapies.

Participants needed: 388
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityUpdated: Nov 27, 2023
Eligibility criteria

Patients with tinnitus as the main complaint: the patients subjectively feel the... [+4]

Patients with conductive deafness, history of middle ear surgery, pulsatile tinn... [+1]