TMJ Pain

6

Review clinical trials related to TMJ Pain. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Double-blind, Placebo-controlled Evaluation of the Effect of the Erchonia® EVRL on Chronic Jaw Pain Arising From TMJ

The purpose of this clinical study is to determine the effectiveness of the Erchonia EVRL, manufactured by Erchonia Corporation (the Company), in providing temporary relief of nociceptive musculoskeletal chronic jaw pain arising from temporomandibular joint (TMJ).

Participants needed: 64
Trial details
Age: 22-75Biological sex: AllType: InterventionalSponsor: Erchonia CorporationUpdated: May 20, 2026Locations: 1
Eligibility criteria

Able to understand and voluntarily sign the IRB-approved informed consent form. [+9]

Pain that is undiagnosed or determined by a qualified medical/dental professiona... [+15]

Status: Not yet recruiting

Biologic Augmentation of TMJ Arthroscopy Using BMAC

The goal of this clinical trial is to learn about the efficacy of using Bone Marrow Aspirate Concentrate (BMAC) during temporomandibular joint (TMJ) arthroscopy compared to standard arthroscopic procedures with corticosteroid (CS) injections in patients with pain (arthralgia) of the temporomandibular joint (TMJ) that has failed to respond to conservative treatment. The main question it aims to answer: Does BMAC injection reduce the amount of inflammation and structural damage in the TMJ? Researchers will compare BMAC injection to corticosteroid injections see if BMAC injection helps . Participants will : * Be randomized to receive either BMAC or CS injection during TMJ arthroscopy * Visit the clinic for 3 follow up visits over 6 months and answer questionnaires * have 2 MRIs of their jaw

Participants needed: 20
Trial details
Phase: Phase 3Age: 18-75Biological sex: AllType: InterventionalSponsor: Weill Medical College of Cornell UniversityUpdated: Apr 17, 2026Locations: 1
Eligibility criteria

Participant is at least 18 years of age and not older than 75 years of age [+3]

Participant has not competed at least 30 days of conservative therapy [+10]

Status: Not yet recruiting

Efficacy of Triamcinolone-Lidocaine Mix in Trigger Points Injection of Masseter Muscle: Double-blinded, Randomized Controlled Trial

This study aims to clinically evaluate the efficacy of trigger points using active drug mix (Triamcinolone with lidocaine) on relief of myofascial pain of jaw muscle.

Participants needed: 30
Trial details
Phase: Phase 2, Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Mar 3, 2026
Eligibility criteria

Age more than or equal 18 years [+2]

Patients who will be using any medications to reduce the pain and/or have any ef... [+4]

Status: Recruiting

Art-Based Pain Assessment Tool in Patients With Temporomandibular Joint Disorders

Title of Study: Assessment of the Impact of Art-Based Pain Assessment Tool on Pain Communication, Joint Function, and Anxiety in Patients with Temporomandibular Disorders (TMD): A Randomized Controlled Trial Location: King Abdulaziz University Dental Hospital (KAUFD), Jeddah, Saudi Arabia What Is This Study About? This study examines how an art-based tool can help improve communication and understanding of pain among patients with jaw joint disorders (TMD). It compares two groups: * Standard care: Routine diagnostic and therapeutic procedures * Intervention: Standard care plus a guided art-based tool using paintings to express and discuss the TMD experiences What Is the Art-Based Tool? This novel method, called the Artistic Pain Exploration (APE), uses paintings to help patients describe their pain that relates to TMD and its effect on their quality of life: 1. Participants will be shown three paintings (e.g., The Scream by Edvard Munch) 2. Participants will choose the one that best resonates with them 3. A guided discussion follows, exploring how the image relates to their physical and emotional pain as well as the effect of pain on their daily activities Research Questions: 1. Does using the APE method help participants better communicate and understand their pain? 2. Does it improve jaw function and reduce anxiety more than standard assessment? Who Can Participate? Participants may be eligible if they: * Are 18 years or older * Have early-stage TMD (not needing surgery) * Can give informed consent Participants cannot participate if they: * Require jaw surgery * Have severe mental illness (e.g., psychosis or bipolar disorder) * Take narcotic pain medications regularly What Will Happen During the Study? * Participants are randomly assigned to one of the two groups. * Each participant will complete a standardized questionnaire before and after two weeks to assess the level of anxiety. * All participants will be screened for depression via a standardized questionnaire before the first visit. * All will undergo a clinical exam to assess the TMJ pain and function and receive appropriate medications and lifestyle instructions. * Some participants (intervention group) will also discuss their pain using the artwork. * All participants will be seen for a follow up in 2 weeks to assess the TMJ function and pain. Potential Risks and Discomforts Participants may experience: * Emotional discomfort while discussing pain * Mild anxiety during interviews or questionnaires If needed, a psychiatrist on the research team will provide support or referrals. Potential Benefits * A better understanding of pain * Improved communication with care provider * Possible improvement in pain and jaw function Costs There are no costs to participate. All treatments are provided free of charge. Compensation / Treatment for Injury * If participants experience harm from this study, necessary medical care will be provided by the research team. * No financial compensation will be provided by King Abdulaziz University. Confidentiality Participants' identity and medical records will remain confidential. Only approved researchers and auditors will have access to data, in accordance with applicable laws. Any results published will not include participants' name or identifying details.

Participants needed: 70
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: King Abdulaziz UniversityUpdated: Jun 15, 2025Locations: 1
Eligibility criteria

Adults aged 18 years or older [+2]

Patients requiring surgical intervention for TMD [+2]

Status: Recruiting

Nerve Block Treatment for Chronic Jaw Pain

Study Summary: Nerve Block Treatment for Chronic Jaw Pain This study is being conducted at the TMJ (temporomandibular joint) clinic, which is part of the oral and maxillofacial surgery department. The goal is to evaluate how effective peripheral nerve blocks are in reducing long-term jaw pain in patients with chronic temporomandibular disorders (TMD) who haven't responded to at least two other types of treatment (such as physical therapy, medication, or bite splints). What Is the Treatment? Peripheral nerve blocks are injections that temporarily block nerve signals from the painful area. This can relieve pain and improve function. These blocks are already used routinely at the clinic. Who Can Join? Adults who have had jaw joint pain for over a year. Have tried at least two other treatments without success. Are mentally competent and not pregnant. What Will Participation Involve? You'll receive the nerve block treatment as part of your regular care. You'll be asked to attend follow-up visits, typically one every 4 months (3 per year). You'll be monitored for pain relief, mouth opening ability, and use of pain medications. You can stop participating at any time without affecting your care. How Will Data Be Handled? Your information will be stored securely and coded to protect your identity. Only the research team will have access to your personal information. How Many People Will Be in the Study? The goal is to recruit 40 patients.

Participants needed: 40
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Bnai Zion Medical CenterUpdated: Jun 10, 2025Locations: 1
Eligibility criteria

Adults (non-pregnant) with sound judgment [+2]

not meeting inclusion criteria [+1]

Status: Recruiting

Topical Treatment for TMJ Arthralgia

The goal of this clinical trial is to evaluate the efficacy of topical 2.5% hydrocortisone in TMJ arthralgia. The main questions it aims to answer are: * How does pain reduction compare? * How does improvement in jaw function limitation compare? * How do side effects compare? Participants will * On day 1 be examined and report their pain level and jaw function limitation * On days 1-21, apply their cream four times a day * On day 21, report their pain level, jaw function limitation, compliance with instructions, and side effects. Researchers will compare topical 2.5% hydrocortisone and topical 1% diclofenac to see if efficacy and side effects differ.

Participants needed: 90
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: University of the PacificUpdated: Dec 11, 2024Locations: 1
Eligibility criteria

Arthralgia of at least 1 TMJ for at least 3 days

Systemic pain condition [+5]