Total Knee Arthroplasty (Postoperative Pain)

4

Review clinical trials related to Total Knee Arthroplasty (Postoperative Pain). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Femoral Triangle Block vs Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty

The goal of this clinical trial is to compare the effects of femoral triangle block (FTB) and adductor canal block (ACB) on early quadriceps function after total knee arthroplasty (TKA). The main question it aims to answer is whether FTB causes more early quadriceps functional impairment than ACB under a standardized multimodal analgesia protocol. Researchers will compare FTB and ACB using a composite binary functional outcome measured 6 hours after block completion. Quadriceps functional impairment is defined as the inability to perform a structured straight leg raise or quadriceps muscle strength \<50% of the preoperative baseline. Participants will be randomly assigned to receive ultrasound-guided FTB or ACB. All participants will also receive a popliteal plexus block and standardized multimodal analgesia.

Participants needed: 136
Trial details
Age: 20+Biological sex: AllType: InterventionalSponsor: Social Medical Corporation DaiyukaiUpdated: Apr 16, 2026Locations: 1
Eligibility criteria

Adult patients (≥ 20 years of age) are scheduled to undergo primary unilateral T... [+5]

Known allergy or contraindication to local anesthetic agents used in this study. [+5]

Status: Not yet recruiting

NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty

The goal of this clinical trial is to learn if the NEUROCUPLE device can reduce pain and opioid use after primary unilateral total knee arthroplasty (TKA) in adults. The main questions it aims to answer are: * Does the NEUROCUPLE device reduce postoperative pain at rest during the first 24 hours after TKA? * Does the NEUROCUPLE device reduce opioid consumption during the first 24 hours after TKA? Researchers will compare the NEUROCUPLE device to a placebo device (identical in appearance but inactive) to see if the device reduces pain and opioid use after surgery. Participants will: * Apply the NEUROCUPLE device or placebo device for 7 days following surgery * Have their pain and opioid use monitored through clinical records and patient reporting * Report pain at rest and during movement on postoperative Days 2 and 7 * Be assessed for nausea, vomiting, device-related side effects, length of hospital stay, and overall satisfaction

Participants needed: 274
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Jacques E. ChellyUpdated: Apr 8, 2026Locations: 3
Eligibility criteria

>18 years of age [+1]

Children (<18 yr.) [+8]

Status: Recruiting

REIKI IN TOTAL KNEE ARTHROPLASTY PATIENTS (REIKI TKA )

Total knee arthroplasty (TKA) is commonly performed to improve mobility and quality of life in patients with degenerative joint diseases. However, severe postoperative pain, limited mobilization, and fluctuations in vital signs negatively affect recovery, particularly within the first 72 hours after surgery. Reiki is a non-invasive complementary therapy aimed at enhancing the body's self-healing capacity through energy transfer. This randomized controlled trial aims to evaluate the effects of Reiki on postoperative pain, mobilization, and vital signs in patients undergoing total knee arthroplasty. Participants will be randomly assigned to either a Reiki intervention group or a control group receiving routine postoperative care. Outcomes will be assessed using validated pain and mobility scales and objective vital sign measurements at the 24th, 48th, and 72nd postoperative hours.

Participants needed: 90
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Ondokuz Mayıs UniversityUpdated: Mar 2, 2026Locations: 1
Eligibility criteria

Adults aged 18 years and older [+4]

Refusal to participate in the study [+10]

Status: Recruiting

Effects of tDCS Combined With CBI on Postsurgical Pain

The purpose of this study is to determine whether a new medical technology can help reduce post-operative total knee or hip pain when combined with a Cognitive-Behavioral intervention (CBI). This new medical technology, is called transcranial direct current stimulation (tDCS), it uses a very small amount of electricity to temporarily stimulate specific areas of the brain thought to be involved in pain reduction. The electrical current passes through the skin, scalp, hair, and skull and requires no additional medication, sedation, or needles. This study will investigate the effects of tDCS, the Cognitive-Behavioral (CB) intervention and their combination on pain among veterans following total knee arthroplasty (TKA) or total hip arthroplasty (THA). The Veteran may benefit in the form of decreased pain and opioid requirements following knee or hip replacement surgery. However, benefit is only likely if Veterans are randomized to one of the 3 (out of 4) groups. This study hopes to determine the effects of these interventions and combined effect on post-operative pain, opioid use and functioning during the 48-hour post-operative period following a total knee or hip replacement.

Participants needed: 132
Trial details
Age: 18-90Biological sex: AllType: InterventionalSponsor: VA Office of Research and DevelopmentUpdated: Jul 30, 2025Locations: 1
Eligibility criteria

Mentally capable of reading, writing, giving consent, and following instructions [+2]

implanted medical devices above the waist [+4]