Transfusion-dependent Non-severe Aplastic Anemia

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Review clinical trials related to Transfusion-dependent Non-severe Aplastic Anemia. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

CsA+EPAG/HPAG+Romiplostim N01 in Newly-diagnosed SAA/TD-NSAA

This study aimed to explore the efficacy and safety of cyclosporine (CsA) +eltrombopag (EPAG)/hetrombopag (HPAG)+romiplostim N01 in the treatment of newly-diagnosed transfusion-dependent aplastic anemia (TD-NSAA) and severe aplastic anemia (SAA)

Participants needed: 43
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Peking Union Medical College HospitalUpdated: Apr 30, 2026
Eligibility criteria

Age ≥ 18 years old; [+6]

Had other primary or secondary bone marrow failure (BMF) diseases, such as Fanco... [+11]

Status: Not yet recruiting

Enarodustat + CsA vs CsA in Newly Diagnosed TD-NSAA

This study aimed to compare the efficacy and safety of enarodustat combined with cyclosporine versus cyclosporine monotherapy in the treatment of newly-diagnosed tansfusion-dependent non-severe aplastic anemia (TD-NSAA).

Participants needed: 90
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Peking Union Medical College HospitalUpdated: Apr 23, 2026
Eligibility criteria

Age ≥ 18 years old; [+5]

Had other primary or secondary bone marrow failure (BMF) diseases, such as Fanco... [+10]

Status: Not yet recruiting

Treatment of Transfusion-dependent Nonsevere Aplastic Anemia With Luspatercept: a Multicenter Prospective Clinical Study

The goal of this clinical trial is to learn whether Luspatercept alone or in combination with Deferasirox can promote hematopoietic function in patients with transfusion-dependent non-severe aplastic anemia, as well as to assess the safety and efficacy of this treatment approach. The main questions it aims to answer is: whether the combination therapy of Luspatercept and Deferasirox can improve hemoglobin levels in these patients. Participants will receive Luspatercept every 3 to 5 weeks based on hemoglobin response, undergo complete blood counts every 1 to 3 weeks, and receive other necessary evaluations as required.

Participants needed: 90
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: The First Affiliated Hospital of Zhejiang Chinese Medical UniversityUpdated: May 11, 2025Locations: 1
Eligibility criteria

The patient has not received and does not consider HSCT or ATG treatment for at... [+5]

1. Severe hepatic dysfunction (ALT or AST ≥ 3 × ULN); 2.Severe renal impairment...