Status: Not yet recruiting
PET/CT Imaging in Carriers of TTR Mutations
The purpose of this study is to determine if TTR gene carriers have early signs of a type of heart disease called amyloidosis using a new radiotracer dye (iodine-124 evuzamitide, I-124E). Participants will undergo a screening that includes a medical history review and completion of quality-of-life surveys. Once screening is complete, participants will undergo an imaging test called a positron emission tomography (PET) scan combined with computed tomography (PET/CT) to make images of the body. The new radiotracer dye (I-124E, a radioactive contrast) will be used during the PET/CT to make amyloidosis visible in the heart and body.
Participants needed: 80
Trial details
Age: 30-80Biological sex: AllType: ObservationalSponsor: University of Texas Southwestern Medical CenterUpdated: May 19, 2026Locations: 1
Eligibility criteria
men and women ages 30-80 who are pathogenic allele TTR carriers without history... [+48]