Treatment-Related Acute Myeloid Leukemia

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Review clinical trials related to Treatment-Related Acute Myeloid Leukemia. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Venetoclax Basket Trial for High Risk Hematologic Malignancies

This trial is evaluating the safety and tolerability of venetoclax with chemotherapy in pediatric and young adult patients with hematologic malignancies, including myelodysplastic syndrome (MDS), acute myeloid leukemia derived from myelodysplastic syndrome (MDS/AML), and acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL). The names of the study drugs involved in this study are below. Please note this is a list for the study as a whole, participants will receive drugs according to disease cohort. * Venetoclax * Azacitidine * Cytarabine * Methotrexate * Hydrocortisone * Leucovorin * Dexamethasone * Vincristine * Doxorubicin * Dexrazoxane * Calaspargase pegol * Hydrocortisone

Participants needed: 30
Trial details
Phase: Phase 1Age: 1-40Biological sex: AllType: InterventionalSponsor: Andrew E. Place, MDUpdated: Mar 12, 2026Locations: 5
Eligibility criteria

MDS with excess blasts (>10%) [+89]

Use of strong or moderate CYP3A inhibitors/inducers within 3 days of study entry [+27]