Trigger Finger

11

Review clinical trials related to Trigger Finger. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Betamethasone vs Dextrose Injections in Trigger Finger

This study aims to compare the effectiveness of ultrasound-guided betamethasone and dextrose injections in patients with trigger finger. Trigger finger is a common hand condition characterized by pain, clicking, and locking of the finger due to tendon entrapment at the A1 pulley. Corticosteroid injections are widely used as a first-line treatment; however, they may be associated with potential side effects. Dextrose injection is an alternative treatment that may promote tissue healing through regenerative mechanisms. However, there is limited high-quality evidence regarding its effectiveness in trigger finger. In this randomized controlled trial, patients will be assigned to receive either betamethasone or dextrose injection under ultrasound guidance. The primary outcome will be pain intensity measured by the Numeric Rating Scale (NRS). Secondary outcomes will include triggering severity, hand function, grip and pinch strength, and fine motor skills evaluated over a 12-week follow-up period. The results of this study may help determine whether dextrose injection is a safe and effective alternative to corticosteroid treatment in trigger finger.

Participants needed: 42
Trial details
Age: 18-75Biological sex: AllType: InterventionalSponsor: Istanbul University - CerrahpasaUpdated: Jul 2, 2026Locations: 1
Eligibility criteria

Age between 18 and 75 years [+2]

Previous surgery on the affected finger [+10]

Status: Not yet recruiting

Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Digital Monitoring System

This study investigates whether early changes observed during the first weeks of hand and upper extremity rehabilitation can predict patient outcomes months later. In rehabilitation practice, clinicians make numerous decisions each session regarding exercise type, frequency, duration, and treatment approach. Most of these decisions are currently made without systematic longitudinal data. This study addresses three fundamental questions using data collected during routine clinical care: (1) Can the rate of improvement in the first weeks of treatment predict functional status months later, across both session-based and milestone-based time points? (2) Are there meaningfully different recovery profiles among hand rehabilitation patients? (3) Is there measurable variation in clinical decision-making among patients with similar profiles, and does this variation relate to outcomes? A digital patient monitoring platform developed by the principal investigator, a physiotherapist and academic researcher specializing in hand rehabilitation serves as the data collection infrastructure. The platform records standard clinical assessment measures in a structured format and has been in active clinical use at Hacettepe University prior to this study. For research purposes, the system has been expanded to include structured capture of patient-reported outcomes, patient global impression of change, treatment protocol coding, home exercise adherence, and automated calculation of early response metrics. This is a 12-month prospective observational cohort study enrolling a minimum of 60 patients. Data are stored securely on the university's institutional network. Patients are anonymized using identification codes. The study is subject to Hacettepe University Ethics Committee approval and participant informed consent. Findings are expected to generate evidence supporting data-driven clinical decision-making in rehabilitation and to provide a feasibility foundation for a larger multi-center study.

Participants needed: 60
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Hacettepe UniversityUpdated: Apr 13, 2026Locations: 1
Eligibility criteria

Adults aged 18 years or older [+4]

• Active psychiatric illness precluding participation or completion of assessmen... [+4]

Status: Recruiting

Prospective Randomized Trial Comparing Longitudinal vs. Transverse A1 Pulley Release

The goal of this clinical trial is to compare two different skin incisions used in surgery to treat trigger finger in adult patients. Trigger finger occurs when a finger gets stuck or locks because of swelling of the sheath around the tendons the help move the fingers. The main questions it aims to answer are (1) Does the type of skin cut affect how well the hand works 6 weeks after surgery? (2) Does the type of skin cut affect pain levels, scar healing, and how quickly people return to their normal activities? Orthopaedic surgeons will compare a straight incision along the finger (longitudinal incision) to a incision across the crease in the palm (transverse incision) to see if one type of incision results in better recovery, less pain, a better scar, and higher patient satisfaction with the procedure. Participants who have trigger finger and are indicated for surgery will have surgery to release the pulley in their finger using one of the two types of incisions (assigned by chance). Participants will fill out questionnaires about their hand function and pain before surgery and at follow-up visits. Participants will have their scar checked and rated at about 2, 6, and 12 weeks after surgery, and report on their pain for the first few days after surgery and when they can return to work and move their finger without pain.

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Washington University School of MedicineUpdated: Apr 8, 2026Locations: 2
Eligibility criteria

Adult patients (age ≥ 18 years) [+2]

Revision surgery [+2]

Status: Not yet recruiting

Comparison of Two Surgical Techniques for the Treatment of Trigger Fingers: Longitudinal Opening Versus Complete A1 Pulley Release

Trigger finger is a pathology of the flexor tendons caused by inflammation of the tendon or its sheath, leading to pain, nodules, fibrosis, and limited mobility. Surgical treatment aims to release the space at the level of the A1 pulley, either through longitudinal opening (the standard technique, but associated with recurrence rates of approximately 7.7%) or through complete resection, an emerging approach that may reduce recurrences and the need for reoperations. However, comparative data remain limited, justifying further investigation. This project therefore aims to compare these two surgical techniques to determine which one results in the lowest recurrence rate and to assess their functional outcomes (pain, range of motion). The primary hypothesis is that A1 pulley resection reduces recurrences after one year, while the secondary hypothesis is that there is no significant difference in postoperative pain or mobility.

Participants needed: 236
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Centre hospitalier de l'Université de Montréal (CHUM)Updated: Mar 31, 2026
Eligibility criteria

Patients requiring surgical intervention for the treatment of a trigger finger [+1]

History of surgery for trigger finger correction on the same finger [+1]

Status: Recruiting

Conservative Treatment of Trigger Finger

This study is to analyze the effectiveness of a nighttime extension orthosis after receiving a cortisone injection for the treatment of trigger finger to improve pain and restore functional outcomes. The investigators hypothesize that the extension orthosis will improve pain and functional outcomes compared to those without a digital night extension orthosis in those with trigger finger at 12 weeks from the injection.

Participants needed: 146
Trial details
Age: 18-100Biological sex: AllType: InterventionalSponsor: Cedars-Sinai Medical CenterUpdated: Mar 27, 2026Locations: 2
Eligibility criteria

Individuals 18 years old or older are included [+2]

Any records flagged with break the glass or research opt out [+4]

Status: Recruiting

Comparative Evaluation of Finger Splint, Paraffin, and Peloidotherapy Interventions in the Management of Trigger Finger

Patients aged 18-75 years who present with trigger finger to a tertiary rehabilitation hospital and agree to participate will be included in the study. Participants will be randomly allocated into three groups using block randomization. The first group will use a static finger splint that blocks the proximal interphalangeal joint for 6 weeks, along with a home exercise program. The second group will receive paraffin bath therapy, and the third group will receive peloidotherapy, both in combination with home exercises. All patients will receive education about the disease and activity modification. The finger joint-restricting splint and exercises will be applied for 6 weeks. Evaluations will be conducted at baseline, at the end of the 3rd week, and at the end of the 6th week by a blinded assessor. No analgesic or anti-inflammatory medication will be permitted during the study, and patients will be instructed to avoid using analgesics within 24 hours prior to each assessment.

Participants needed: 60
Trial details
Age: 18-75Biological sex: AllType: InterventionalSponsor: Konya Beyhekim Training and Research HospitalUpdated: Mar 19, 2026Locations: 1
Eligibility criteria

Being between 18 and 75 years of age and willing to participate in the study [+1]

Patients with triggering in more than one finger [+13]

Status: Recruiting

Effectiveness of Conservative Interventions in the Treatment of Trigger Finger

There is no study in the literature comparing the effectiveness of ESWT and splint therapy, which are the most commonly used approaches in the treatment of Trigger Finger (TF). The aim in this study is to investigate the effectiveness of ESWT and splint therapy used in the treatment of TF.

Participants needed: 54
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Sep 9, 2025Locations: 1
Eligibility criteria

Volunteering [+3]

Being pregnant [+5]

Status: Not yet recruiting

The Effects of a Structured Hand Exercise Program on Trigger Finger: A Randomized Controlled Trial

To explore the effectiveness of a structured hand exercise program as a conservative treatment for trigger finger.

Participants needed: 76
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: The Hong Kong Polytechnic UniversityUpdated: Apr 4, 2025Locations: 1
Eligibility criteria

Adults with aged > 18 years old who are diagnosed with trigger finger [+2]

Pediatric or congenital trigger finger [+2]

Status: Recruiting

Efficacy of Ultrasound-Guided Needle Knife Release for Trigger Finger

Efficacy of ultrasound-guided tri-directional needle knife release in treating patients with trigger finger. The study evaluates safety, effectiveness, and recovery outcomes of a minimally invasive procedure compared to conventional approaches.

Participants needed: 46
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Mohamed Maher Ismail Ahmed ElashmawyUpdated: Jan 27, 2025Locations: 1
Eligibility criteria

Idiopathic TF at the level of A1 pulley [+3]

Patients with secondary causes of TF like diabetes mellitus, rheumatoid arthriti... [+5]

Status: Not yet recruiting

Comparing the Effects of Extracorporeal Shockwave Therapy and Splinting in the Treatment of Trigger Finger

The goal of this study is to compare the effects of extracorporeal shockwave therapy and splinting in the treatment of trigger finger. Participants will: Be randomized into two groups (shockwave group and splint group). Visit the clinic once a week for four weeks for therapy. Keep a diary of their symptoms, which will be reviewed at six weeks.

Participants needed: 24
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Mahidol UniversityUpdated: Dec 24, 2024
Eligibility criteria

Patients age ≥ 18 years [+2]

Trigger thumb [+2]

Status: Not yet recruiting

Effectiveness of Audiovisual Versus Written Postoperative Instructions for Patients Undergoing Minor Hand Procedures

The utility and effectiveness of video-based instructions (VBI) versus standard written instructions was not previously investigated in hand surgery; thus, the objective of this study is to evaluate the effectiveness of audiovisual instruction as compared to regular verbal instructions given to patients undergoing common hand procedures, including instruction recall and compliance, patient education, patient satisfaction with the information given, patient satisfaction with operative experience.

Participants needed: 120
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: McGill University Health Centre/Research Institute of the McGill University Health CentreUpdated: Sep 3, 2024
Eligibility criteria

Patient undergoing hand and/or upper extremity surgery with Dr. Thibaudeau [+3]

Patient presenting with intra-articular, open, or pathological fractures [+10]