Typ 2 Diabetes

The goal of this clinical trial is to investigate the influence of morning versus evening concurrent training consisting of high-intensity interval training and resistance training on glycemic control in men with type 2 diabetes mellitus. The main questions it aims to answer are: • Which time is best for concurrent exercise training in diabetic patients, morning or evening? Researchers will compare morning versus evening concurrent training consisting of HIIT and RT on glycemic control in men with type 2 diabetes mellitus. Participants will: * Perform concurrent training consisting of high-intensity interval training and resistance training for 12 weeks * Visit the clinic before and after the 12-week experimental period for checkups and tests

Approval study Trans-Duodenal Barrier The goal of this clinical trial is to determin the safety and performance of the newly developed Trans-Duodenal Barrier in adult Tryp 2 diabetic and obese patients. The Trans-Duodenal Barrier is an endoscopic implant which can be placed to the gastric outlet and the upper small bowel by interventional endoscopy. It consists of a 60 cm long foil tube , a transpyloric shaft and and two ringlike balloons to fix it at the pylorus. It will be removed after 6 months via gastroscopy. The main questions it aims to answer are: * Does the Trans-Duodenal Barrier lower the HbA1c of the participants ? * How frequent are adverse side effects related to the device? * How much ist the excessive wight loss of treated patients ? * Show patients with Metabolic assiociated Hepatosteatitis (MASH) improvements in liver elasticity (elastography) ? Researchers implant the Trans-Duodenal Barrier to enclosed patients and follow up them till 4 weeks after explantation. Participants will: * Get the Trans-Duodenal Barrier as an implant for 6 moths * Visit the clinic 3 times in the implant period and once for explant. * Receive a telefon interview 4 weeks after explant