Urinary Retention

19

Review clinical trials related to Urinary Retention. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Selective Median Lobe Surgery Outcomes Study

This prospective multicenter observational cohort study will evaluate clinical outcomes after selective median lobe transurethral surgery for benign prostatic obstruction. Eligible men with lower urinary tract symptoms or urinary retention who are scheduled for selective median lobe-only TURP, HoLEP, or anatomical endoscopic enucleation as part of routine clinical care will be enrolled and followed after surgery. The study will collect preoperative clinical data, symptom scores, uroflowmetry, postvoid residual volume, prostate volume, intravesical prostatic protrusion measurements, cystoscopic anatomical findings, intraoperative variables, and postoperative outcomes. The primary outcome is composite clinical failure at 12 months. The main aim is to identify practical preoperative urology-based anatomical and functional predictors of clinical failure after selective median lobe surgery and to develop an exploratory prediction model that may help improve patient selection in future practice.

Participants needed: 420
Trial details
Age: 45+Biological sex: MaleType: ObservationalSponsor: Necmettin Erbakan UniversityUpdated: Jul 13, 2026Locations: 2
Eligibility criteria

Male patients aged 45 years or older. [+5]

Previous prostate surgery for benign prostatic hyperplasia. [+6]

Status: Recruiting

Effect of Chlorhexidine Gluconate Bladder Instillations in Patients With Chronic Suprapubic Catheters on Unplanned Healthcare Encounters and Quality of Life

The goal of this clinical trial is to evaluate the feasibility and tolerability of 0.05% Chlorhexidine Gluconate (CGH) bladder instillations in an outpatient setting at the time of suprapubic catheter (SPC) exchange in patients with history of recurrent urinary tract infections (UTI). The main questions are: 1. is instillation of 150mL of CGH for five-minute duration at the time of SPC exchange feasible in an outpatient setting and tolerable for patients. 2. does this protocol decrease the rate of unplanned health care visits and improve patient quality of life. Patients will undergo the treatment protocol during their routine suprapubic catheter exchanges.

Participants needed: 70
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Yale UniversityUpdated: Jun 18, 2026Locations: 1
Eligibility criteria

Indwelling suprapubic catheter with insertion date at least 1 year prior to stud... [+1]

Current radiographic evidence of urolithiasis [+7]

Status: Recruiting

Post-operative Urinary Retention (POUR) Following Thoracic Surgery

Inability to urinate a common complication that happens to many patients after a surgery, especially in men over 60 years of age who undergo surgery on their chest. Urinary retention is uncomfortable, increases anxiety, increases hospital length of stay, and leads to more procedures such as putting in a bladder catheter (Foley). This is uncomfortable, and can lead to bleeding, infection, damage to the urethra and/or bladder and bladder spasm. The goal of this study is to attempt to prevent inability to urinate by giving patients a medication called Flomax (Tamusolin) every day beginning a week before surgery. That medication relaxes the prostate. It's approved by the Food and Drug Administration (FDA) to improve urinary flow in those with enlarged prostates. It is also commonly used in patients with bladder problems due to inability to urinate who have required a Foley.

Participants needed: 127
Trial details
Phase: Phase 1, Phase 2Age: 50+Biological sex: MaleType: InterventionalSponsor: Hackensack Meridian HealthUpdated: Jun 11, 2026Locations: 1
Eligibility criteria

Using Flomax already [+6]

Status: Recruiting

Effect of Catheter Duration on Prostate Laser Enucleation Surgery Outcomes in Patients With Urinary Retention

Benign Prostatic Obstruction (BPO) is a common condition in aging men that can lead to urinary retention, often requiring the use of an indwelling urinary catheter. While laser enucleation of the prostate (such as HoLEP, ThuLEP or ThuFLEP) is a safe and effective surgical treatment, it is not well understood how the length of time a patient spent with a urethral catheter before surgery affects the final surgical outcomes. By analyzing patient data from multiple centers of the Minimally Invasive Urology Society, this study aims to evaluate the impact of preoperative catheterization duration on functional outcomes.

Participants needed: 54
Trial details
Age: 18+Biological sex: MaleType: ObservationalSponsor: Eskişehir Osmangazi University Medicine Faculty HospitalUpdated: May 22, 2026Locations: 1
Eligibility criteria

Patients undergoing laser enucleation of the prostate, including HoLEP, ThuLEP o...

Patients with a diagnosis of neurogenic bladder or prostate cancer.

Status: Not yet recruiting

Comparing Clean Intermittent Self-catheterization and Indwelling Catheterization for the Management of Urinary Retention Before BPH Surgery.

The CATHETERS trial is a multicenter, randomized, open-label superiority study comparing two methods of managing urinary retention before surgery for benign prostatic hyperplasia (BPH): clean intermittent self-catheterization (ICSC) versus indwelling catheter (IDC). The primary objective is to determine whether ICSC reduces the occurrence of infectious complications (urinary bacterial colonization requiring antibiotic therapy, urinary tract infection, or urosepsis) compared to IDC in men awaiting BPH surgery. A total of 106 patients will be enrolled across multiple centers in France, with follow-up extending to three months after surgery.

Participants needed: 106
Trial details
Age: 50+Biological sex: MaleType: InterventionalSponsor: University Hospital, BordeauxUpdated: Apr 29, 2026Locations: 5
Eligibility criteria

Men over 50 years old; [+6]

Patient with a history of prostate surgery (including BPH surgery), prostatic ar... [+8]

Status: Not yet recruiting

Evaluating Two Nursing Interventions to Prevent Urinary Retention After Spinal Anesthesia

The goal of this clinical trial is to learn whether two simple nursing methods can help prevent trouble emptying the bladder (acute urinary retention, AUR) after surgery with numbing medicine in the lower back (spinal anesthesia). Adults having surgery in the scrotum (scrotal), groin (inguinal), pelvic area, lower belly (lower abdominal), or bones and joints (orthopedic surgery) with spinal anesthesia will take part. After surgery, participants will be randomly placed into one of three groups: one group will receive a cold pack on the lower belly (suprapubic area), a second group will receive a gentle massage on the lower back over the tailbone (sacral area), and a third group will receive usual care only with no extra procedure. The same nurse researcher will provide the study care for all groups, check how well participants pass urine, use a small painless scan on the lower belly to see how much urine is in the bladder (portable bladder ultrasound), and record whether a tube in the bladder to drain urine (urinary catheter) is needed.

Participants needed: 105
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Istanbul University - CerrahpasaUpdated: Apr 6, 2026Locations: 1
Eligibility criteria

Age 18 years or older [+7]

Duration of surgery longer than 2 hours [+4]

Status: Recruiting

Effect of Voiding Position (Standing in the Shower vs. Sitting) on Post-Void Residual Urine Volume (PVR) After Removal of Urinary Catheter in Women Following Benign Vaginal Gynecologic Surgery

The goal of this clinical trial is to learn if voiding in a standing position in the shower, rather than sitting on a toilet, may reduce pain associated with the act of voiding, thereby facilitating micturition and decreasing both post-void residual volume and the risk of subsequent urinary retention in women that underwent benign vaginal surgeries.

Participants needed: 100
Trial details
Age: 18-99Biological sex: FemaleType: InterventionalSponsor: Assuta Ashdod HospitalUpdated: Mar 25, 2026Locations: 2
Eligibility criteria

Adult women (≥18 years old). [+5]

Bladder injury during surgery. [+3]

Status: Recruiting

Comparison of Urinary Flow Study

The purpose of this research study is to compare the urinary flow speed of two different female catheters in patients that use intermittent catheters to empty their bladder. The "14 Fr Two Eyelet Coloplast Female SpeediCath Urinary Catheter" will be compared to the "14 Fr Coloplast Micro Zone Luja Female Catheter." Participants will have one study visit that should take about an hour and will also receive a follow-up telephone call about one week after the visit.

Participants needed: 17
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Wake Forest University Health SciencesUpdated: Mar 5, 2026Locations: 1
Eligibility criteria

Female [+3]

Severe urinary tract abnormalities (e.g. excessive production of urinary mucus/s... [+5]

Status: Recruiting

Pelvic Health Electrically Evoked Recording (PEER) 2 Study

To collect physiological signals at several timepoints during the therapy evaluation period.

Participants needed: 300
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: MedtronicNeuroUpdated: Mar 3, 2026Locations: 7
Eligibility criteria

18 years of age or older [+18]

Currently enrolled or planning to enroll in an interventional clinical study tha... [+35]

Status: Recruiting

Post Operative Urinary Retention (POUR) Following Thoracic Oncological Surgery

This is a feasibility study looking at whether the use of Tamsulosin could lower the high incidence of postoperative urinary retention (POUR) in older men who undergo an oncological thoracic surgical procedure for suspected or confirmed cancer. In addition, the study will try to identify the time of resumption of presurgical urinary function post Tamsulosin administration.

Participants needed: 46
Trial details
Phase: Early Phase 1Age: 55+Biological sex: MaleType: InterventionalSponsor: Hackensack Meridian HealthUpdated: Feb 10, 2026Locations: 4
Eligibility criteria

Males [+3]

Using Tamsulosin already [+7]

Status: Not yet recruiting

Rectus Abdominis Detrusor Myoplasty for Urinary Retention

This investigates the outcomes of a surgical technique using the patient's own abdominal wall muscles to help contract the bladder in patients with urinary retention

Participants needed: 50
Trial details
Age: 18-75Biological sex: AllType: ObservationalSponsor: University Hospitals Cleveland Medical CenterUpdated: Jan 30, 2026Duration: 1 Year
Eligibility criteria

Hypo- or acontractility of the bladder documented on urodynamic testing [+4]

Documented bladder outlet obstruction [+5]

Status: Recruiting

Define Final Selection Choice Criteria for a Coloplast Catheter Ensuring Highest Patient Satisfaction Via Surveys (EVA).

Understanding the Coloplast Intermittent Catheter Selection Study: This study aims to understand how adults who need to use catheters to empty their bladder by themselves decide which Coloplast catheter works best for them. The two types of catheters studied are called SpeediCath and Luja. Why is this study being done? The study wants to find out which catheter type helps people feel most satisfied when they start to use it on their own. It also looks at why people choose their catheter at the beginning, how happy they are with it over the first six months, and what problems they might face using it. Who can join the study? * Adults aged 18 or older who have bladder problems and need to empty their bladder using a catheter. * People who have been trained on how to use a catheter. * People who have chosen to use either SpeediCath or Luja catheters from Coloplast. * People who can perform the catheterization themselves at least two times per day. Certain people cannot join, such as pregnant women, anyone who cannot give consent, or those who have trouble filling out questionnaires. What will happen in the study? Participants will visit the study center three times: * At the start (to select their catheter and answer questions about the reasons for the specific catheter selection) * After 3 to 12 weeks (to share their perception on the impact of the used catheter) * After 6 months (to measure final satisfaction and any difficulties) If a participant changes to a different catheter type or catheter brand during the study, this will be recorded, and they will continue in the study. How will this study help? The information gathered will help healthcare providers understand what matters most to people when selecting a catheter. This can improve how catheters are recommended and support patients better during self-catheterization and improve treatment adherence and compliance.

Participants needed: 107
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Coloplast NV/SAUpdated: Jan 21, 2026Locations: 1
Eligibility criteria

Female or male aged eighteen years or older; [+8]

Pregnant, parturient or breast-feeding woman; [+8]

Status: Not yet recruiting

Effect of Individualized Catheter Management on Early Removal After Rectal Cancer Surgery

This study aims to systematically evaluate the safety and efficacy of different early urinary catheter removal strategies following radical resection of mid-low rectal cancer. Current clinical practice faces controversy regarding the optimal timing of catheter removal (24 hours vs. 48 hours) and lacks precise preventive measures for patients at high risk of postoperative acute urinary retention (AUR). To address these issues, this study is designed as a three-arm randomized controlled trial, directly comparing three management protocols: catheter removal at 24 hours postoperatively, catheter removal at 48 hours postoperatively, and an individualized strategy guided by a predictive model (i.e., preventive administration of tamsulosin to high-risk AUR patients prior to catheter removal). The primary endpoint is the rate of recatheterization within 7 days after the initial removal, with secondary endpoints comprehensively assessing urinary tract infections, voiding function, and postoperative complications. The ultimate goal is to provide high-quality evidence-based medical evidence to establish a precise and standardized clinical pathway for individualized postoperative catheter management.

Participants needed: 1,545
Trial details
Biological sex: AllType: InterventionalSponsor: The First Hospital of Jilin UniversityUpdated: Jan 16, 2026Locations: 1
Eligibility criteria

Patients with a preoperative pathological confirmation of rectal malignant tumor... [+2]

History of previous abdominal surgery involving the rectum/sigmoid colon/left co... [+9]

Status: Recruiting

Evaluation of the Efficacy of the Addition of Magnesium Sulfate to Morphine on the Occurrence of Acute Urinary Retention Following Epidural Anesthesia for Cesarean Section.

Peri-medullary anesthesia is the preferred anesthetic technique for Caesarean surgery. Compared with general anesthesia, it reduces maternal and fetal morbidity and mortality, as well as postoperative pain. However, this technique exposes the patient to the adverse effects of peri-medullary morphine, particularly the risk of postoperative urinary retention. Urinary retention during the first 72 hours after Caesarean section affects around 33% of parturients. This is a particularly debilitating event for parturients, exposing them to the risk of further urinary catheterization, increased theoretical risk of urinary tract infection, traumatic urethral injury, hindered accelerated rehabilitation and altered maternal satisfaction. Several studies have demonstrated the benefits of adding magnesium sulfate to epidural anesthesia for Caesarean sections, notably by reducing postoperative pain. Magnesium sulfate may also have a facilitating effect on postoperative micturition, thanks to its sympathicolytic effect. This hypothesis is supported by a retrospective study carried out in our maternity hospital, which showed a 15% reduction in post-Caesarean urinary retention when women were given magnesium sulfate in addition to the drugs traditionally used for epidurals. This little-known property needs to be clarified

Participants needed: 290
Trial details
Phase: Phase 4Age: 18+Biological sex: FemaleType: InterventionalSponsor: CHU de ReimsUpdated: Dec 30, 2025Locations: 1
Eligibility criteria

Patients who have undergone scheduled or emergency Caesarean section surgery und... [+4]

Minor patients [+8]

Status: Not yet recruiting

Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia.

The purpose of this study is to investigate the effect of neuraxial analgesia initiation on the incidence of pruritus in laboring women. Specifically, this study aim to compare intrathecal fentanyl with epidural fentanyl in order to determine whether the epidural route is associated with a lower occurrence and severity of pruritus. By clarifying these differences, the research seek to optimize analgesic strategies during labor while minimizing opioid-related side effects

Participants needed: 80
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: St. Justine's HospitalUpdated: Nov 26, 2025Locations: 1
Eligibility criteria

Age ≥ 18 years [+4]

ASA score > 3 [+9]

Status: Recruiting

Preoperative Pelvic Floor Physical Therapy to Minimize Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate

The purpose of this study is to allow us to assess the effectiveness (or success) of starting pelvic floor physical therapy (i.e. exercises for your pelvic muscles) prior to HoLEP (holmium laser enucleation of the prostate) surgery for enlarged prostates in order to manage or prevent urinary incontinence (i.e. leaking) after surgery (i.e. post-operatively). Your pelvic floor refers to the muscles under your bladder along your pelvic bones that prevent you from leaking urine or stool. Traditionally, pelvic floor physical therapy is started after surgery and continued until urinary continence (i.e. no leaking of urine) is regained. We want to assess if beginning pelvic floor physical therapy prior to surgery (and continuing afterwards) reduces the time required to regain urinary continence following HoLEP.

Participants needed: 36
Trial details
Age: 18+Biological sex: MaleType: InterventionalSponsor: The Cleveland ClinicUpdated: Aug 21, 2025Locations: 1
Eligibility criteria

Age: >=18 years of age [+4]

Neurological disorders: patients with a history of a neurologic disorder that co... [+4]

Status: Not yet recruiting

RElax & feeL at EASE (RELEASE)

This multicenter, parallel-group, randomized controlled trial (RELEASE) aims to evaluate the efficacy of two educational approaches on acceptance and adherence to intermittent catheterization (IC) among adult male patients. Participants requiring IC training will be randomized to either an enhanced educational intervention (informational booklet, video tutorial, and standard training) or standard clinical practice training alone. The primary outcome is the change in Intermittent Catheterization Acceptance Test (I-CAT) scores over three months. Secondary outcomes include adherence (I-CAS), urinary symptoms (USQNB-IC), patient autonomy, satisfaction with assistive technology (QUEST), and functional abilities. The study seeks to identify the most effective educational strategy to improve psychological acceptance, promote adherence, and reduce complications in patients performing IC, ultimately supporting patient-centered care and health system efficiency.

Participants needed: 64
Trial details
Age: 18+Biological sex: MaleType: InterventionalSponsor: Stefania MuscoUpdated: Jul 24, 2025
Eligibility criteria

Male patients aged 18 years or older. [+4]

Presence of cognitive impairment limiting ability to understand or perform IC in... [+4]

Status: Recruiting

Effect of Urethral Balloon Dilatation on Urinary Retention After Spinal Cord Injury

Trial Objectives: This clinical trial aims to explore whether ultrasound - guided urethral balloon dilation can effectively improve the micturition function of patients with urinary retention after spinal cord injury, and to evaluate the safety of this treatment method. The main questions it attempts to answer are: Can ultrasound - guided urethral balloon dilation reduce the residual urine volume and improve the quality of life of patients with urinary retention after spinal cord injury? Trial Design: Researchers will compare the group receiving ultrasound - guided urethral balloon dilation combined with conventional rehabilitation therapy (the experimental group) with the group receiving only conventional rehabilitation therapy (the control group) to determine the therapeutic effect of ultrasound - guided urethral balloon dilation on urinary retention after spinal cord injury. Tasks for Participants: Participants in the experimental group will receive ultrasound - guided urethral balloon dilation and cooperate with conventional rehabilitation therapy (including acupuncture therapy, pelvic floor biofeedback electrical stimulation, and pelvic floor function training). Participants in the control group will receive only conventional rehabilitation therapy for a period of 1 - 2 weeks. During the intervention, patients are required to strictly record a micturition diary under the guidance of researchers or medical staff. The diary should cover details such as daily spontaneous urine output, daily catheterized urine output, daily urine leakage volume, and daily frequency of catheterization. Residual urine volume will be detected every day for three days before the intervention and three days after the intervention.

Participants needed: 74
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Qilu Hospital of Shandong UniversityUpdated: May 18, 2025Locations: 1
Eligibility criteria

Age between 18-80 years old [+7]

Patients with severe heart, brain, lung and other important organ diseases or me... [+3]

Status: Recruiting

Efficacy of Alpha-blockers (Tamsulosin) in the Treatment of Symptomatic Dysuria in Multiple Sclerosis in Women

Multiple sclerosis (MS) is the leading non-traumatic cause of severe acquired disability in young people. The disease is defined by relapses, which can affect all neurological functions depending on the location of the new inflammatory lesion(s). The disease can thus manifest itself through bladder and bowel disorders (BWS), which affect approximately 80% of MS patients in all stages. Lower urinary tract dysfunction has a significant negative impact on the quality of life of patients and places a significant burden on the healthcare system in terms of resource allocation. In addition, there is a risk of long-term chronic renal failure, an infectious risk (recurrent cystitis and/or pyelonephritis, sometimes life-threatening) and a lithiasis risk. The most frequently observed urinary symptoms are: urinary frequency, urgency with or without urinary incontinence, dysuria and chronic retention of urine. These disorders most often combine bladder hyperactivity and dysuria. This dysuria may be responsible for recurrent urinary tract infections, lithiasis, alteration of renal function. The only therapeutic class currently used to treat dysuria in MS is alpha-blockers. Tamsulosin, alfusozin and doxazosin induce relaxation of the urethral smooth sphincter and prostatic urethral muscle fibers, facilitating the removal of subvesical obstruction and bladder emptying. The study investigators hypothesize that treatment with tamsulosin 0.4 mg daily in adult MS patients with dysuria will result in symptom improvement as assessed by the International Prostate Symptom Score (IPSS) and Urinary Symptom Profile (USP) scores, a decrease in post-void residual, and an improvement in urine flow and quality of life.

Participants needed: 60
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Centre Hospitalier Universitaire de NīmesUpdated: Jun 25, 2024Locations: 1
Eligibility criteria

The patient must have given their free and informed consent and signed the conse... [+4]

The subject is participating in another category 1 interventional study, or a tr... [+13]