Health Trials

Uterine Carcinosarcoma

2

Review clinical trials related to Uterine Carcinosarcoma. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.

Participants needed: 200
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Volastra Therapeutics, Inc.Updated: Nov 4, 2025Locations: 14
Eligibility criteria

All Parts: Age ≥ 18 years, ECOG Performance Status ≤ 1, at least 1 site of measu... [+2]

MSI-H, dMMR, POLE gene hotspot mutated, or known hypermutator phenotype [+6]

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Status: Recruiting

EPOCH: Eribulin and Pembrolizumab in Ovarian/Uterine Carcinosarcoma

The EPOCH study population is patients with tubo-ovarian carcinosarcoma or uterine carcinosarcoma with evidence of recurrence or progression. The study aims to determine the activity of eribulin as a single agent and the combination of eribulin and pembrolizumab as measured by clinical benefit rate (CBR) at 12 weeks. Additionally, the study aims to establish whether high mobility group A2 (HMGA2) protein expression is a good functional biomarker to predict response to eribulin and pembrolizumab.

Participants needed: 30
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Australia New Zealand Gynaecological Oncology GroupUpdated: Feb 4, 2025Locations: 6
Eligibility criteria

Provision of written informed consent prior to any study specific procedures and... [+17]

Prior line of treatment involving immunotherapy with an anti-PD-1, anti-PD-L1, o... [+19]

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