Valve Disease, Heart

11

Review clinical trials related to Valve Disease, Heart. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Hummingbird ICE Study

The goals of this observational study are to collect data and ultrasound images using the Philips VeriSight Pro intracardiac echocardiography (ICE) catheter to assess safety and effectiveness and to support development efforts of the VeriSight Pro imaging platform.

Participants needed: 1,000
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Philips Clinical & Medical Affairs GlobalUpdated: May 22, 2026Duration: 2 Days
Eligibility criteria

18 years of age [+2]

Contraindicated for ICE catheter placement or considerations that make placement... [+1]

Status: Not yet recruiting

Soft Foam Dressings for Pressure Injury Prevention of Cardiac Surgery

The purpose of this study is to evaluate whether the application of soft foam dressings can reduce the occurrence of surgery-related pressure injuries among patients undergoing cardiac surgery. Specifically, this research aims to investigate differences in pressure injury outcomes before and after the intervention, and to assess the preventive effectiveness of soft foam dressings as an adjunctive skin-protection strategy.

Participants needed: 80
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Shih,Wen-ChiUpdated: May 14, 2026
Eligibility criteria

Adults aged 18 years or older [+4]

Surgical position other than supine [+3]

Status: Recruiting

Observational Study of Patients Undergoing Diagnostic Right Heart Catheterization

The objective of this observational pilot study is to collect HemoCept device data from subjects undergoing diagnostic right heart catheterization (RHC) procedures.

Participants needed: 50
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: HemoCept Inc.Updated: Apr 13, 2026Locations: 1
Eligibility criteria

Subjects or representatives must have voluntarily signed the informed consent fo... [+4]

Subject is pregnant, breastfeeding, or intends to become pregnant during this st...

Status: Recruiting

Medtronic Cardiac Surgery PMCF Registry

This registry is being conducted to support ongoing post-market surveillance activities.

Participants needed: 2,700
Trial details
Biological sex: AllType: ObservationalSponsor: Medtronic Cardiac SurgeryUpdated: Apr 13, 2026Locations: 26Duration: 10 Years
Eligibility criteria

Patient or legally authorized representative provides written authorization and/... [+2]

Patient who is, or is expected to be, inaccessible for follow-up [+2]

Status: Not yet recruiting

Apixaban VS Warfarin in AF Pts First Three Months After Repair or BIO AVR MVR

SAFE-HEART is a single-centre, randomized controlled trial comparing the safety and efficiency of Apixaban versus Warfarin in the early period (3 months) after repair or bioprosthetics of the mitral and aortic valve cardiac surgery in patients with atrial fibrillation requiring oral anticoagulation.

Participants needed: 120
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Meshalkin Research Institute of Pathology of CirculationUpdated: Feb 25, 2026Locations: 1
Eligibility criteria

Age ≥18 years at the time of enrolment [+3]

Mechanical valve replacement [+8]

Status: Recruiting

Mosaic Mitral Valve: Long-Term Outcomes in Patients Under 65

The safety and efficacy of the Mosaic bioprosthetic heart valves for cardiac valve replacement in the aortic position has been well documented throughout the literature. However, few studies assessing structural valve deficiency, patient outcomes and overall product performance in patients under the age of 65 exists for the Mosaic mitral valve bioprosthetic. This study aims to assess valve efficacy, stability, and post operative outcomes in patients who have received the Mosaic mitral valve prothesis at ProMedica Toledo Hospital and were under the age of 65.

Participants needed: 300
Trial details
Age: 18-65Biological sex: AllType: ObservationalSponsor: Michael MorontUpdated: Feb 20, 2026Locations: 1
Eligibility criteria

Received the Mosaic Mitral Valve Bioprosthetic at ProMedica Toledo Hospital [+1]

Over the age of 65 [+2]

Status: Recruiting

Valvular Heart Disease in Women Registry

Valvular heart disease (VHD) is a major global health issue. Untreated rheumatic heart disease persists in many regions, preventable with timely care. Higher-income countries face rising calcific valve disease from aging, worsened by VHD complications, like infective endocarditis, resulting in higher morbidity/mortality. Gender disparities in VHD remains understudied, despite inequalities in risks, diagnosis, and treatment. Prevalence varies by gender, but uneven diagnostics and therapies obscure realities. This registry will examine gender disparities from hospital admission to first outpatient follow-up, recruiting both men and women to investigate and report the study objectives.

Participants needed: 800
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Valvular Heart Disease in Women RegistryUpdated: Sep 29, 2025Locations: 2Duration: 1 Year
Eligibility criteria

Adult patients with diagnosis of any VHD according to the current ESC guidelines... [+1]

Age less than 18 years old. [+1]

Status: Recruiting

Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence

The aim of this study is to evaluate feasibility, efficacy, and adherence of home-based cardiac rehabilitation with the integration of telemedicine. Several components will be assessed such as quality-of-life, nutritional counseling, maximum metabolic activity (MET's), diabetic management, tobacco cessation, lipid, blood pressure, and psychosocial management. These tasks will be accomplished through concurrent conversations between patients and their therapist's utilizing telemedicine with observed exercise training.

Participants needed: 500
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: ROM Technologies, INCUpdated: Jul 24, 2025Locations: 1
Eligibility criteria

Over the age of 18 [+3]

Under the age of 18 [+8]

Status: Recruiting

The Asia-Pacific Mitral & Tricuspid Valve-in-Valve/Valve-in-Ring Registry (AP ViV Registry)

A retrospective and prospective, observational, multicenter cohort study of consecutive patients undergoing transcatheter mitral/tricuspid ViV or ViR procedure with balloon expandable valve across participating sites in Asia-Pacific.

Participants needed: 150
Trial details
Age: 21+Biological sex: AllType: ObservationalSponsor: National Heart Centre SingaporeUpdated: Jul 10, 2025Locations: 8
Eligibility criteria

Age ≥ 21 [+1]

Active endocarditis [+1]

Status: Recruiting

Allogeneic Valve Transplantation

Valves will be taken from hearts donated by organ donors, and implanted into patients who need a new heart valve.

Participants needed: 4
Trial details
Age: 30-50Biological sex: AllType: InterventionalSponsor: Boston Children's HospitalUpdated: Sep 24, 2024Locations: 1
Eligibility criteria

Patients requiring aortic, pulmonary, mitral or tricuspid valve replacement. [+7]

Age < 30 days [+17]

Status: Recruiting

The ENDOCARDITIS AUMC Data Collection

The investigators will compare patients with and without infective ndocarditis undergoing valve surgery and evaluate factors that may help optimise perioperative care of these high-risk patients.

Participants needed: 3,000
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Updated: Jul 25, 2023Locations: 1Duration: 10 Years
Eligibility criteria

Patients > 18 years [+3]

Previous history of coagulation disorders