Valvular Diseases

3

Review clinical trials related to Valvular Diseases. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Intrapleural Ropivacaine Infusion in Cardiac Surgery

For many patients, a primary source of postoperative pain following cardiac surgery is the presence of pleural drains, which the surgeon places at the end of the operation and maintains for 1 to 3 days. One promising method of pain management after cardiac surgery is interpleural analgesia, particularly when traditional analgesic methods, such as systemic opioids or epidural anesthesia, may be limited due to the risk of complications. Interpleural analgesia involves the introduction of local anesthetics directly into the pleural cavity through drainage tubes placed after cardiac surgery. This method targets pain receptors in the chest area, providing effective analgesia without significant systemic effects. Several clinical studies have confirmed the safety and efficacy of intrapleural administration of anesthetics after thoracic surgery. The aim of this randomised double-blind placebo controlled study is to test the hypothesis that, in patients after cardiac surgery, the quality of recovery from anesthesia with intrapleural use of ropivacaine is superior to that with a placebo.

Participants needed: 116
Trial details
Phase: Phase 4Age: 18+Biological sex: AllType: InterventionalSponsor: Saint Petersburg State University, RussiaUpdated: Mar 10, 2026Locations: 2
Eligibility criteria

Scheduled cardiac surgery using a standard median sternotomy. [+3]

Contraindications for ropivacaine [+1]

Status: Recruiting

Factors Affect Outcomes in Cardiovascular Surgery

Identify factors that contribute to perioperative morbidity and mortality in patients undergoing cardiac surgery that involves cardiopulmonary bypass. Identify factors that affect perioperative morbidity and mortality in patients undergoing cardiac surgery.

Participants needed: 5,000
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: University of California, DavisUpdated: Feb 12, 2026Locations: 1
Eligibility criteria

Not listed

Status: Not yet recruiting

Effectiveness of Remote Cardiac Rehab After Surgery for Acquired Heart Valve Disease

The goal of this clinical trial is to learn if home-based cardiac rehabilitation using remote monitoring devices improves exercise capacity in patients after surgery for acquired heart valve diseases. It also aims to learn about factors affecting the outcomes of remote treatment. The main questions it seeks to answer are: * How does cardiac rehabilitation using remote monitoring devices improve exercise capacity in participants compared to those undergoing rehabilitation at medical facilities? * What factors influence the outcomes of participants undergoing cardiac rehabilitation with remote monitoring devices? The researchers compare the exercise capacity of the intervention group - receiving home-based cardiac rehabilitation using remote monitoring devices - with that of the control group receiving treatment at a rehabilitation facility during the recovery phase. All patients participating in the study receive inpatient cardiac rehabilitation during the acute phase (1 week) and the early recovery phase (1 week) at the hospital. The control group continues supervised outpatient rehabilitation at the hospital, three sessions per week for the following month. The intervention group undergoes home-based rehabilitation under the guidance of a therapist via the Open TeleRehab platform and self-monitors hemodynamic parameters using a personal blood pressure monitor and a handheld pulse oximeter. Both groups are assessed for exercise capacity at baseline (pre-surgery), after each phase of rehabilitation, and one month after hospital discharge.

Participants needed: 44
Trial details
Age: 18-70Biological sex: AllType: InterventionalSponsor: Hanoi Medical UniversityUpdated: May 22, 2025Locations: 1
Eligibility criteria

Patients undergoing first-time surgery for acquired heart valve diseases (valve... [+1]

Contraindications to cardiac rehabilitation. [+1]