Violence

14

Review clinical trials related to Violence. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Hospital-based Intervention for Youth Injured Through Violence

The firearm violence epidemic is a major public health problem, especially for youth. Every day in the US, approximately 100 people fall casualty to firearms through forms of violence, such as homicide, suicide, and unintentional or accidental injuries. Among youth, firearm violence remains the leading cause of death, and each year the rate of firearm-related mortality is increasing. Beyond the significant and devastating cost of human life, firearm violence is an enormous economic burden to the US, which totals an estimated $229 billion annually. In urban communities with high rates of firearm-related violence, firearm-related emergency department visits are extremely draining on the hospital system. At the national level, firearm-related injuries account for $2.8 billion annually in emergency department care each.

Participants needed: 360
Trial details
Age: 13-17Biological sex: AllType: InterventionalSponsor: Virginia Commonwealth UniversityUpdated: Jul 2, 2026Locations: 1
Eligibility criteria

Aged 13-17 years old [+1]

Youth aged <13 years and >17 years old [+2]

Status: Recruiting

Evaluating the Effectiveness of the Common Elements Treatment Approach (CETA) in Peru: Mechanisms of Individual and Intergenerational Change

Recent advances in intervention research have revealed the promise of transdiagnostic, modular approaches implemented by lay paraprofessionals for the treatment of the most prevalent mental health concerns in settings affected by adversity (e.g., anxiety, depression, posttraumatic stress), but to date, few effectiveness trials have examined the indirect effects of treatment on intergenerational and economic outcomes or moderators of treatment effectiveness. There is thus a critical need not only for the continued expansion of the evidence-basis for care in low-resource settings, but also for the evaluation of factors contributing to effectiveness across multiple dimensions to gain a better understanding of the sustainability, long-term benefits, and cost-effectiveness of these approaches. The current study will conduct a rigorous evaluation of an existing program, the Common Elements Treatment Approach (CETA) with women (N=300) who are mothers of young children (ages 4-6). The trial will take place in the context of an integrated community care setting in Lima, Peru's most populous and impoverished district, San Juan de Lurigancho. The primary aims are to (1) evaluate the primary and indirect effects of CETA (2) examine moderators of treatment effectiveness, including implementation quality and neighborhood factors and (3) examine CETA's cost effectiveness. The central hypotheses are that (H1a) CETA will improve women's mental health, intimate partner violence, and parenting and that (H1b) CETA will have indirect benefits for women's economic outcomes and for their children's adjustment. It is also hypothesized (H2) that effectiveness will be enhanced by strong implementation quality and the presence of neighborhood promotive factors, and weakened by neighborhood disadvantage. Hypotheses will be evaluated using an RCT employing a longitudinal design with assessments at baseline (T1), post-test (T2), 6-month follow-up (T3) and 12-month follow-up (T4). Women will be randomized into the intervention condition (CETA + Enhanced Case Management \[ECM\]) or the comparison condition (ECM). Robust, multi-source (i.e., participant, therapist, supervisor, census data) and multi-method data (i.e., interview, observational assessment, google street view coding) will be gathered. The contribution will be significant by advancing research on both direct and long-term benefits of maternal mental health care for family systems, and is likely to provide important insights into the sustainability and cost effectiveness of these approaches. The expected outcome is an evidence-based, cost-effective, integrated approach to maternal mental health care that can be readily implemented by local organizations. Further, it is anticipated that learnings from this project will respond to broader global public health concerns and provide opportunity for cross-context reciprocal innovation. Expanding the evaluation of CETA delivered in Spanish not only has advantages for the specific context under study, but provides an important foundation for addressing health disparities in Spanish-language mental health services in the US as well.

Participants needed: 600
Trial details
Phase: Phase 2Age: 18+Biological sex: FemaleType: InterventionalSponsor: University of Notre DameUpdated: Jun 25, 2026Locations: 1
Eligibility criteria

live in San Juan de Lurigancho, Lima, Peru, [+3]

living outside of San Juan de Lurigancho, [+2]

Status: Recruiting

A Virtual Reality Brief Violence Intervention: Preventing Gun Violence Among Violently Injured Adults

The overall aim of the proposed project is to develop and evaluate the effectiveness of Brief Violence Intervention-Virtual Reality (BVI-VR) for reducing firearm-related violence, re-injury, and mortality among victims of violence. Outcome measures of firearm-related violence will come from multiple sources, including criminal background checks, hospital data, state-level data, semi-structured clinical assessments, and self-report assessments. In addition, the study aims to understand the impact of BVI-VR on psychosocial mediators resulting in a reduction of firearm-related violence. This will include self-report surveys, neurocognitive assessments, and clinical assessments. The economic efficiency of BVI-VR as a firearm-related violence intervention will also evaluated. To achieve these aims, a randomized control trial (RCT) in a large sample of violently injured adults (18+ years) from VCU Health will be conducted.

Participants needed: 220
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Virginia Commonwealth UniversityUpdated: Jun 10, 2026Locations: 1
Eligibility criteria

violently injured patients from VCU's Level 1 Trauma Center [+2]

Under 18 years old [+1]

Status: Recruiting

Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study

The purpose of the study is to evaluate a trauma informed digital multicomponent intervention design to improve health and safety outcomes for women with lifetime exposures to violence and co-occurring PTSD and/or depression symptoms

Participants needed: 676
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Johns Hopkins UniversityUpdated: May 6, 2026Locations: 1
Eligibility criteria

age 18 or older [+2]

Participants who don't meet the above criteria

Status: Recruiting

An Evidence-based Family Support Program for Parents and Children in Palestine: A Theory-based Intervention

Few evidence-based programs exist to support children and families affected by sociopolitical conflict, despite documented evidence of their heightened risk for emotional and behavioral adjustment problems associated with exposure to conflict and violence at multiple levels of the social ecology (e.g., political, community, and family). Thus, a critical need exists for an evidence-based program to ameliorate the impact of political violence on the overall well-being of children and families. The current study will conduct a rigorous evaluation of a theoretically-driven, family-based intervention program in Palestine, including both the West Bank and Gaza. Firmly grounded in the cultural context of Palestine but with broad implications for individuals exposed to sociopolitical violence, the long-term goal of this project is to provide a family-focused intervention program (Promoting Positive Family Futures; PPFF) that may facilitate individuals' sense of safety and support in the context of chronic adversity. The objective is to evaluate this intervention program in the context of a randomized clinical trial (RCT) in the West Bank and Gaza (N=300). The central hypothesis is that the program will have direct positive effects on family conflict, parent psychopathology and parental security in the family as well as on adolescent emotional security in the family, with cascading effects on adolescent adjustment. Consistent with family systems theory, we further hypothesize that treatment effects on parents will mediate on the effects of the treatment on adolescent adjustment. The rationale is that bolstering resilience in family systems is a key approach to promoting positive functioning in families exposed to chronic violence. The hypothesis will be evaluated with three specific aims: 1) evaluate the efficacy of an evidence-based family support program; 2) examine process models of treatment change, and 3) examine interrelations between parent and child functioning. To achieve these aims, the study will be an RCT employing a longitudinal design (N=300) with multi-method assessments at baseline (T1), post-test (T2), 6-month follow-up (T3) and 12-month follow-up (T4). Families included in the study will be evenly divided between the West Bank (n=150) and Gaza Strip (n=150). Families will be randomized into the intervention condition (PPFF) or treatment as usual (TAU). Each territory will have an implementing partner, and implementing partners and investigators will work together to ensure the study procedures are implemented in parallel across sites. Data collection will be conducted by trained research staff from a third-party survey and policy research organization. The proposal seeks to shift current research and clinical paradigms in these contexts by employing novel theoretical concepts, approaches, and methodologies. The contribution will be significant by 1) further developing new directions for empirically-based interventions in these high-risk contexts, and 2) advancing a relatively brief, cost-effective program that can be readily implemented to help children and families exposed to continuing conflict in Palestine, with the potential to be brought to scale in other contexts.

Participants needed: 900
Trial details
Age: 12-75Biological sex: AllType: InterventionalSponsor: University of Notre DameUpdated: Apr 23, 2026Locations: 1
Eligibility criteria

a willing adolescent between the ages of 13 and 16 [+2]

Families with individuals with significant mental or physical impairments preclu...

Status: Not yet recruiting

Creative Drama on Gender Role Stress, Attitudes Toward Violence Against Women, and Aggression

This study aims to examine the effect of Creative Drama on gender role stress, attitudes toward violence against women, and aggression among men who experienced the February 6, 2023 earthquake in Türkiye (centered in Kahramanmaraş). A total of 75 men (25 experimental, 25 placebo, and 25 control) will participate in the study. The experimental group will take part in a creative drama program, the placebo group will watch films focusing on masculinity roles and violence for 10 weeks, and no intervention will be applied to the control group. Data will be collected using the Gender Role Stress Scale for Men, the Attitudes Toward Violence Against Women Scale, and the Buss-Perry Aggression Questionnaire - Short Form, and will be analyzed by an independent statistician. The study aims to enhance the psychological well-being of men affected by the earthquake in Türkiye, reduce violence against women, and contribute to gender equality.

Participants needed: 75
Trial details
Age: 18-65Biological sex: MaleType: InterventionalSponsor: Ataturk UniversityUpdated: Apr 9, 2026
Eligibility criteria

Not listed

Status: Recruiting

Preventing Retaliatory Gun Violence in Violently Injured Adults

The purpose of this research study is to find out if a hospital-based violence intervention (Bridging the Gap) is effective for reducing violence. The researchers think that adults who receive Bridging the Gap will see greater improvements than those who do not receive the intervention. This study will allow them to learn more about the intervention's effectiveness. The study will also help them understand if the violence intervention affects other behaviors, such as firearm use, drug use, aggression, risky behaviors, and rates of violent re-injury.

Participants needed: 616
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Virginia Commonwealth UniversityUpdated: Feb 4, 2026Locations: 1
Eligibility criteria

They receive treatment in the hospital for a violence-related injury (e.g., guns... [+3]

Non-English speaking [+2]

Status: Recruiting

Cognitive Remediation in Forensic Mental Health Care

Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a challenge to forensic rehabilitation. One empirically-validated method to train executive functions is cognitive remediation, which consists of cognitive exercises combined with coaching. This trial investigates whether cognitive remediation can improve cognitive, functional, and clinical outcomes in forensic inpatients.

Participants needed: 30
Trial details
Age: 18-55Biological sex: AllType: InterventionalSponsor: The Royal Ottawa Mental Health CentreUpdated: Dec 12, 2025Locations: 1
Eligibility criteria

Not listed

Status: Recruiting

Evaluation of the Effect of the BOAT® Structured Prevention Program on Violence in Middle Schools

Violence has major consequences for the health and development of children and teenagers, even though it is commonplace, particularly in secondary schools. The team at the Centre Ressources pour les Intervenants auprès d'Auteurs de Violences Sexuelles Languedoc-Roussillon (CRIAVS-LR, CHU Montpellier) has created a BOite A ouTils to prevent sexual and gender-based violence: the BOAT, for professionals working with children and teenagers aged between 5 and 18. Structured around 5 themes and 4 age groups, the BOAT is very easy to use. The 134 intervention sheets have been validated and designed to target a risk factor (to be reduced) or a protective factor (to be developed) so that children do not become perpetrators or victims of violence.

Participants needed: 5,400
Trial details
Age: 13-17Biological sex: AllType: ObservationalSponsor: University Hospital, MontpellierUpdated: Aug 24, 2025Locations: 1
Eligibility criteria

Middle school students: students enrolled in a middle school included in the stu... [+1]

Schoolchildren: opposition to participation in the search by the child's parents... [+3]

Status: Recruiting

Addressing Root Causes for Gun Violence Prevention (ARC-GVP)

The goal of this study is to help build the evidence base for a locally-relevant youth firearm violence prevention program in Washington D.C., a city experiencing disparities in youth firearm violence outcomes. The main question it aims to answer is: How is youth participation in the summer youth employment program, the True Reasons I Grabbed the Gun Evolved from Risk (The T.R.I.G.G.E.R Project), which is designed to address root causes of gun violence, associated with individual youth behavioral outcomes, including pro-social involvement, aggression, and firearm-related attitudes and behaviors?

Participants needed: 250
Trial details
Age: 14-24Biological sex: AllType: ObservationalSponsor: University of MichiganUpdated: Aug 14, 2025Locations: 1
Eligibility criteria

Youth in Washington D.C. who are participating in The T.R.I.G.G.E.R Project, a g...

Emancipated minors

Status: Recruiting

The Mother in Norway Study

The Norwegian government is implementing the Nurse Family Partnership program (NFP) to combat child abuse and social inequality. This study will examine NFP with an individually randomized controlled parallel-group trial. The study will enroll 700 mothers over three years, with half receiving NFP services and the other half receiving standard care. The primary outcome is violence towards mothers and their children, assessed through questionnaires and observation tests. The study will also evaluate the program's effects on various health-related outcomes using administrative data. Cost-effectiveness analyses will be conducted to compare NFP to existing services and improve its delivery efficiency.

Participants needed: 700
Trial details
Age: 16+Biological sex: FemaleType: InterventionalSponsor: Oslo Metropolitan UniversityUpdated: Aug 11, 2025Locations: 5
Eligibility criteria

Not listed

Status: Not yet recruiting

Evaluation of Thriving, Substance Use, Mental Health, and Repeat Injury Among Participants in the THRIVE Program

The goal of this observational study is to determine the impact of a hospital-based violence intervention program on a person's capacity to thrive and recurrent intentional injury. The aims of this study are: 1. To evaluate the impact of the HVIP on building personal capacity of youth who have experienced non-fatal violent injuries to thrive using: * Established measure changes in positive psychology and clinical metrics * A qualitative interview using thematic content analysis 2. Plot the methodology proposed to measure the impact of THRIVE on subsequent injuries using administrative data sources Participants will complete surveys, participate in a semi-structured interview, and have their rate of recurrent intentional injury tracked over time. Researchers will compare the rates of intentional reinjury between participants in the THRIVE program and those who present at other hospitals with similar injuries to see if there is a difference in the rate of recurrent intentional injury a 1, 5, and 10 years.

Participants needed: 90
Trial details
Age: 14-29Biological sex: AllType: ObservationalSponsor: Unity Health TorontoUpdated: Jun 13, 2024
Eligibility criteria

ages 14-29 [+2]

unable to consent due to language barrier or brain injury [+4]

Status: Recruiting

Preventing Physical and Emotional Violence by Teachers in Public Schools in Pakistan

Violence has severe and long-lasting negative consequences for children and adolescents' well-being and psychosocial functioning, thereby also hampering communities and societies' economic growth. Studies show high prevalence rates of violence by teachers against children in Pakistan. In addition to legal and structural factors (e. g. stressful working conditions for teachers), attitudes favoring violence against children as an effective and acceptable discipline method and the lack of access to alternative non-violent strategies are likely to contribute to teachers' ongoing use of violence against children. Notwithstanding, there are currently very few school-level interventions to reduce violence by teachers that a) have been scientifically evaluated and b) that focus both on changing attitudes towards violence and on equipping teachers with non-violent discipline strategies. Thus, the present study tests the effectiveness of the preventative intervention Interaction Competencies with Children - for Teachers (ICC-T) in secondary schools in Pakistan. Previous studies have provided initial evidence on the feasibility to implement teacher violence interventions in secondary schools in Pakistan. This study aims to provide first evidence for the effectiveness of ICC-T to reduce violence and to improve children's functioning (i.e. mental health, well-being, academic performance) in Pakistan.

Participants needed: 2,100
Trial details
Age: 11-62Biological sex: AllType: InterventionalSponsor: Bielefeld UniversityUpdated: Apr 9, 2024Locations: 1
Eligibility criteria

Not listed

Status: Recruiting

Dundrum Forensic Redevelopment Evaluation Study: D-FOREST Study.

The DUNDRUM Forensic Redevelopment Evaluation study (D-FOREST study) is a multi-site comprehensive evaluation of a complete National Forensic Mental Health Service. The study will have a prospective, observational, longitudinal design which will permit the evaluation of benefit over time for individual patients, groups of patients and the evaluation of the benefit in terms of service based outcomes of the redevelopment of a complete National Forensic Mental Health Service e.g. effects on waiting list times, length of stay. The study will systematically evaluate multiple domains of recovery in a complete National Forensic Service, including patients' physical health, mental health, offending behaviours and social and occupational functioning.

Participants needed: 350
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Health Service Executive, IrelandUpdated: Oct 12, 2021Locations: 1
Eligibility criteria

Admitted to the National Forensic Mental Health Service (NFMHS) Ireland after 1s...

This study comprises a complete cohort of admissions to the NFMHS. All adult pat...