Health Trials

X-linked Retinoschisis

4

Review clinical trials related to X-linked Retinoschisis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

ATSN-201 Gene Therapy in RS1-Associated X-linked Retinoschisis

This study will evaluate the safety and efficacy of ATSN-201 in subjects ≥ 6 years of age with RS1-associated X-linked retinoschisis (XLRS).

Participants needed: 97
Trial details
Phase: Phase 3Age: 6+Biological sex: AllType: InterventionalSponsor: Atsena Therapeutics Inc.Updated: Apr 30, 2026Locations: 4
Eligibility criteria

Age ≥ 18 for Cohorts 1 through 4, and age ≥ 6 years and < 18 years for Cohort 5. [+3]

Pre-existing eye conditions in the study eye that would contribute significantly... [+12]

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Status: Recruiting

Development and Evaluation of Functional Visual Field and Navigation Endpoints in Moderate to Profound Inherited Retinal Disease (DEFINE-IRD)

The Vision Research and Assessment Institute (VRAI) was established with the purpose of serving as a testing facility for efficacy endpoints for patients with Low Vision. The mission of the VRAI is to enable the highest quality, standardized efficacy testing of patients with visual impairment. The VRAI facilitates the development and refinement of existing endpoints specifically for testing patients with Low Vision.

Participants needed: 25
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Ray Therapeutics, Inc.Updated: Mar 31, 2026Locations: 1
Eligibility criteria

Diagnosis of bilateral retinitis pigmentosa (RP) or other retinal dystrophies im... [+2]

Cognitive impairment, memory loss or dementia sufficient in severity to preclude... [+2]

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Status: Recruiting

Safety and Efficacy of a Single Subretinal Injection of JWK002 Gene Therapy in Subjects With X-linked Retinoschisis(XLRS)

This trial is to evaluate the safety and efficacy of JWK002 treatment of X-linked retinoschisis(XLRS). This study will enroll subjects aged 5-18 years old to receive a sub-retinal injection of JWK002.

Participants needed: 12
Trial details
Phase: Early Phase 1Age: 5-18Biological sex: MaleType: InterventionalSponsor: West China HospitalUpdated: Feb 7, 2025Locations: 1
Eligibility criteria

Fully understand the purpose and requirements of the trial, voluntarily particip... [+3]

Carbonic anhydrase inhibitor treatment within 3 months; [+11]

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Status: Recruiting

Safety and Efficacy Study of LX103 Treatment of X-Linked Retinoschisis (XLRS)

The goal of this study is to evaluate the safety and efficacy of LX103 treatment of X-linked retinoschisis. This study will enroll subjects aged ≥ 6 years old to receive a single unilateral intravitreal (IVT) injection of LX103 to evaluate its safety and efficacy.

Participants needed: 12
Trial details
Age: 6+Biological sex: MaleType: InterventionalSponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineUpdated: Apr 18, 2023Locations: 1
Eligibility criteria

Willing to sign the informed consent, and willing to attend follow-up visits. [+2]

Any eye with disease that would interfere with the fundus examinations. [+3]

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