Health Trials

Clinical trials

2

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Condition / disease
Location
Status: Recruiting

A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

The primary objective of this study is to characterize the safety and tolerability of loncastuximab tesirine in combination with polatuzumab vedotin, glofitamab, or mosunetuzumab, and to identify the maximum tolerated dose (MTD) and/or recommended dose for expansion (RDE) for the combinations.

Participants needed: 200
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: ADC Therapeutics S.A.Updated: Jun 9, 2026Locations: 42
Eligibility criteria

Male or female participant aged 18 years or older [+23]

Known history of hypersensitivity resulting in treatment discontinuation to or p... [+30]

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Status: Recruiting

A Study to Evaluate the Pharmacokinetics and Safety of Loncastuximab Tesirine in Participants With Relapsed or Refractory Diffuse Large B-cell Lymphoma or High-grade B-cell Lymphoma With Hepatic Impairment (LOTIS-10)

The primary objective of this study is to determine the recommended dosing regimen of loncastuximab tesirine in diffuse large B-cell lymphoma (DLBCL) or high-grade B-cell lymphoma (HGBCL) participants with moderate and severe hepatic impairment.

Participants needed: 56
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: ADC Therapeutics S.A.Updated: Jul 16, 2025Locations: 14
Eligibility criteria

Male or female participants aged 18 years or older [+8]

Previous therapy with loncastuximab tesirine [+9]

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