Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

The purpose of this study is to compare the efficacy and safety of ficlatuzumab plus cetuximab compared to placebo plus cetuximab in participants with recurrent/metastatic (R/M) HPV-negative Head and Neck Cancer. The primary hypothesis is that ficlatuzumab combined with cetuximab is superior to cetuximab alone in terms of progression-free survival and/or overall survival.

Participants needed: 410
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: AVEO Pharmaceuticals, Inc.Updated: Apr 9, 2026Locations: 112
Eligibility criteria

Male or female and ≥ 18 years of age [+11]

Participants who have received > 2 prior lines of anticancer therapy or prior tr... [+13]

Read more
Status: Recruiting

A Dose Escalation Study of AV-380 in Cancer Patients With Cachexia

This open label ascending dose study is designed to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of AV-380 in cancer patients with Cachexia. AV-380 is an immunoglobulin (Ig) G1 monoclonal antibody (mAb) intended to bind circulating human growth differentiation factor 15 (GDF-15), a cytokine involved in cancer-induced cachexia.

Participants needed: 30
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: AVEO Pharmaceuticals, Inc.Updated: Jan 8, 2026Locations: 12
Eligibility criteria

Patient must be ≥ 18 years of age at the time of signing the informed consent. [+5]

History of allergic or anaphylactic reaction to any monoclonal antibody (IgG pro... [+5]

Read more