Health Trials

Clinical trials

3

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma

This trial will evaluate the safety and tolerability of a single unilateral administration of one of three dose levels of AAVAnc80-antiVEGF and will evaluate the Akouos delivery device to safely achieve the intended product performance.

Participants needed: 27
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Akouos, Inc.Updated: Apr 6, 2026Locations: 4
Eligibility criteria

Presence of unilateral, progressive vestibular schwannoma. [+8]

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Status: Recruiting

Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss

Part A of this trial will evaluate the safety and tolerability of a single surgical administration procedure in one or both ear(s) with one of two dose levels of AAVAnc80-hOTOF and will evaluate the Akouos Delivery Device, together with the Precision Delivery Mechanism, to safely achieve the intended product performance.

Participants needed: 22
Trial details
Phase: Phase 1, Phase 2Biological sex: AllType: InterventionalSponsor: Akouos, Inc.Updated: Mar 4, 2026Locations: 9
Eligibility criteria

Participants may be of any age, based on Cohort Criteria [+7]

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Status: Recruiting

Otoferlin Gene-mediated Hearing Loss Natural History Study

This is a retrospective and prospective longitudinal study in participants with Otoferlin Gene-Mediated Hearing Loss.

Participants needed: 150
Trial details
Age: Up to 44Biological sex: AllType: ObservationalSponsor: Akouos, Inc.Updated: Mar 4, 2026Locations: 10
Eligibility criteria

Clinical presentation of bilateral sensorineural hearing loss (SNHL), including... [+3]

Unwillingness or inability of the potential participant and/or legally authorize... [+4]

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