Clinical trials

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Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Phase 1 Study of ABF-101 in Single- and Multiple-Ascending Doses

This is a Phase 1 study to evaluate the safety, tolerability, PK, and PD of ABF-101 in healthy participants and participants with age-related macular degeneration (AMD).

Participants needed: 68
Trial details
Phase: Phase 1Age: 18-50Biological sex: AllType: InterventionalSponsor: Aptabio Therapeutics, Inc.Updated: Feb 6, 2026Locations: 1
Eligibility criteria

Part A and B [+11]

Part A and B [+25]

Status: Recruiting

A Phase 1 Study of APX-343A as Monotherapy or in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

This is a Phase 1, open-label, dose-escalation study to assess the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of APX-343A monotherapy (Part A) and in combination with pembrolizumab (Part B) in subjects with advanced solid tumors.

Participants needed: 110
Trial details
Phase: Phase 1Age: 19+Biological sex: AllType: InterventionalSponsor: Aptabio Therapeutics, Inc.Updated: Nov 19, 2025Locations: 3
Eligibility criteria

Male or female subjects aged ≥19 years, inclusive, at the time of informed conse... [+12]

Received any prior immunotherapy. [+19]

Status: Recruiting

Efficacy and Safety Study of Isuzinaxib in Subjects With DKD

This study is a multicenter, double-blinded, randomized, placebo-controlled, dose-ranging study to evaluate the safety, tolerability, PK, and efficacy of Isuzinaxib compared with placebo in subjects with DKD.

Participants needed: 186
Trial details
Phase: Phase 2Age: 19+Biological sex: AllType: InterventionalSponsor: Aptabio Therapeutics, Inc.Updated: Jul 18, 2025Locations: 20
Eligibility criteria

Male/female subject aged ≥19 years inclusive at the time of informed consent. [+11]

History of type 1 diabetes mellitus or gestational diabetes. [+20]