Health Trials

Clinical trials

5

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Phase 1, Open-label Trial of Belzupacap Sarotalocan (AU-011) in Bladder Cancer

The main objectives of this study are to determine the feasibility and safety of Belzupacap Sarotalocan (AU-011, bel-sar) treatment of bladder cancer utilizing focal injections with or without laser application.

Participants needed: 55
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Aura BiosciencesUpdated: Apr 15, 2026Locations: 17
Eligibility criteria

Multifocal LG Ta; OR [+11]

Any additional malignancy that requires active treatment, unless deemed appropri... [+4]

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Status: Recruiting

Suprachoroidal Administration in Subjects With Metastases to the Choroid

The primary objective is to assess the safety and tolerability of bel-sar treatment in subjects with metastases to the choroid from any primary solid tumor.

Participants needed: 24
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Aura BiosciencesUpdated: Mar 13, 2026Locations: 10
Eligibility criteria

Have a clinical diagnosis of Metastases to the Choroid, from a histopathological... [+1]

Active ocular infection or disease. [+2]

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Status: Recruiting

A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma

The primary objective is to determine the safety and efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melanoma (CM).

Participants needed: 100
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Aura BiosciencesUpdated: Mar 2, 2026Locations: 71
Eligibility criteria

Clinical diagnosis of primary indeterminate lesion or small choroidal melanoma (... [+2]

Have known contraindications or sensitivities to the study drug or laser [+1]

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Status: Not yet recruiting

A Long-Term Follow-Up Study of Subjects Completing the AU-011-301(CoMpass) for Early Choroidal Melanoma

AU-011-403 is a multicenter long-term follow-up safety and efficacy study of subjects with early CM who previously participated in the AU-011-301 Phase 3 trial. There are no required interventions or use of AU-011 (bel-sar) in this long-term follow-up study

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Aura BiosciencesUpdated: Jan 14, 2026
Eligibility criteria

Have received bel-sar or sham treatment in the Aura-sponsored clinical trial AU-... [+1]

None

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