Health Trials

Clinical trials

3

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Available

BRM421 Ophthalmic Solution in Patients With Limbal Stem Cell Deficiency

The goal of this program is to provide patients with Limbal Stem Cell Deficiency access to the BRM421 eye drops. Participants will: * Use BRM421 two times a day for at least 12 weeks * Visit the clinic monthly for checkups and tests

Trial details
Age: 18+Biological sex: AllType: Expanded AccessSponsor: BRIM Biotechnology Inc.Updated: Feb 20, 2026Locations: 1
Eligibility criteria

Adult patients with mild to moderate LSCD who unsatisfied with the standard of c... [+2]

The patients eligible for the BRIM clinical trial(s). [+3]

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Status: Not yet recruiting

A Dose Regimen Study of BRM421 Ophthalmic Solution in Patients With Dry Eye Disease

To evaluate the safety and efficacy of BRM421 Ophthalmic Solution compared to artificial tear for treatment of the signs and symptoms of dry eye disease (DED)

Participants needed: 99
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: BRIM Biotechnology Inc.Updated: Oct 20, 2025Locations: 1
Eligibility criteria

Are ≥18 years of age; [+3]

Within 3 months prior to Visit 1, have participated in any other investigational... [+3]

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Status: Recruiting

Assessment of the Initial Efficacy and Safety of BRM424 Ophthalmic Solutions in Patients With Neurotrophic Keratitis

The objective of this study is to obtain initial efficacy of BRM424 in patients with Stage 2 and Stage 3 NK and evaluate safety and tolerability.

Participants needed: 12
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: BRIM Biotechnology Inc.Updated: Oct 28, 2024Locations: 1
Eligibility criteria

Be at least 18 years of age; [+2]

Any active ocular infection (bacterial, viral, fungal or protozoal) or active oc... [+2]

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