Status: Recruiting
Short-term Effects of an SGLT2 Inhibitor on Divalent Ions in Autosomal Dominant Polycystic Kidney Disease
This study aims to better understand electrolyte handling in patients with autosomal dominant polycystic kidney disease treated with the SGLT2 inhibitor Empagliflozin. Patients will be randomized into two groups and take Empagliflozin or a Placebo for 2 weeks with a wash-out period of 2 weeks. The primary outcome is tubular handling of the divalent ions calcium, phosphate and magnesium. Secondary outcomes include diuresis, safety and tolerability.
Participants needed: 40
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Cantonal Hospital GraubuendenUpdated: Sep 12, 2025Locations: 2
Eligibility criteria
- Patients 18-75 years old with ADPKD, defined according to international diagno... [+1]
- renal replacement therapy or kidney allograft recipient [+13]