Health Trials

Clinical trials

2

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Condition / disease
Location
Status: Not yet recruiting

A Study of CLSP 5282 in HLA-A*03:01 Positive Adult Patients With Solid Tumors (SENTINEL-101)

Phase 1, open-label, multicenter study to evaluate the safety, tolerability, PK, PD, and preliminary clinical activity of CLSP 5282 when administered to HLA A\*03:01-positive adult patients with advanced solid tumors that harbor the KRas G12V mutation.

Participants needed: 140
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Clasp Therapeutics, Inc.Updated: Jun 16, 2026Locations: 4
Eligibility criteria

Adults at least 18 years of age on the day of signing informed consent. [+7]

Patients who have received other KRas G12V directed cellular therapies or TCEs. [+5]

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Status: Recruiting

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Phase 1 dose escalation and expansion study of CLSP-1025, a first-in-class HLA-A\*02:01 specific T cell engager (TCE) targeting solid tumors that harbor the p53 R175H mutation.

Participants needed: 90
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Clasp Therapeutics, Inc.Updated: Feb 13, 2026Locations: 21
Eligibility criteria

Patients must be at least 18 years of age at the time of signing the informed co... [+7]

Patients with Li-Fraumeni syndrome or other known germline p53 R175H mutation [+5]

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