Clinical trials

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Condition / disease
Location
Status: Not yet recruiting

Silent Aspiration Following Extubation in the ICU

Post-extubation dysphagia is common in critically ill patients and may lead to silent aspiration, which often remains undetected because patients do not exhibit overt clinical signs such as coughing or choking. Current bedside nursing swallow screening may fail to identify silent aspiration in patients recovering from prolonged mechanical ventilation. The goal of this observational study is to learn about the incidence, risk factors, and clinical outcomes of silent aspiration in critically ill adult patients who require prolonged mechanical ventilation and are extubated in the ICU. The main questions it aims to answer are: * How often does silent aspiration occur in ICU patients intubated for 5 days or longer after extubation? * Can silent aspiration be present despite passing the routine bedside nursing swallow screen? * What clinical factors are associated with silent aspiration? * Is silent aspiration associated with worse clinical outcomes such as aspiration pneumonia, reintubation, prolonged ICU stay, ventilator-free days, or mortality? Participants who have been mechanically ventilated for 5 days or more will undergo routine bedside swallow screening followed by Fiberoptic Endoscopic Evaluation of Swallowing (FEES), considered the gold-standard diagnostic tool for detecting silent aspiration, within 72 hours after extubation. Researchers will compare bedside nursing swallow screening results with FEES findings to evaluate the diagnostic accuracy of bedside screening in detecting silent aspiration. Clinical data, swallowing assessment findings, and patient outcomes will also be collected and analyzed.

Participants needed: 274
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Cleveland Clinic Abu DhabiUpdated: Jun 9, 2026Locations: 1
Eligibility criteria

Adult ICU patients requiring invasive mechanical ventilation for 5 days or longe... [+4]

Presence of tracheostomy [+4]

Status: Recruiting

Pharmacokinetics of Antibiotics in Patients Undergoing Renal Replacement Therapies

The study is aiming to describe the pharmacokinetic and pharmacodynamic profile of intravenous meropenem, ertapenem, cefepime, colistin, Ceftazidime/Avibactam , Ceftolozane/Tazobactam , and piperacillin/tazobactam in the plasma and determine how much is removed by Renal Replacement Therapies to ensure adequate dosing

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Cleveland Clinic Abu DhabiUpdated: Feb 8, 2023Locations: 1
Eligibility criteria

Adults > 18 year old [+4]

Less than 18 years of age [+9]