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Condition / disease
Location
Status: Recruiting

An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus

This is an exploratory pilot open-label study to identify the signal changes on fMRI of patients with tinnitus and with temporary suppression of the tinnitus with IV lidocaine. Patients will include those with hearing loss (both unilateral and bilateral) and tinnitus, subjects with normal hearing and tinnitus, and control subjects with normal hearing and no tinnitus. Eligible subjects will have functional and subjective data collected at baseline, receive an IV lidocaine infusion, and have functional and subjective data collected post-infusion for comparison and identification of involved neural networks.

Participants needed: 40
Trial details
Phase: Early Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: D. Bradley Welling, MD, PhDUpdated: Dec 2, 2025Locations: 1
Eligibility criteria

Ability to provide informed consent [+4]

Currently undergoing tinnitus treatment with other pharmacologic agents [+11]