Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD

The aim of this study is to evaluate DCR-PHXC in participants with PH1 and severe renal impairment, with or without dialysis.

Participants needed: 28
Trial details
Phase: Phase 2Biological sex: AllType: InterventionalSponsor: Dicerna Pharmaceuticals, Inc., a Novo Nordisk companyUpdated: Dec 24, 2025Locations: 18
Eligibility criteria

adults and adolescents (aged ≥ 12 years) [+16]

Prior hepatic transplantation; or scheduled transplantation within 6 months of D... [+16]

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Status: Recruiting

Safety, Tolerability, and Pharmacokinetics of DCR-PDL1 in Adults With Solid Tumors

The study will evaluate the safety, tolerability, and pharmacokinetics of intravenous DCR-PDL1 in adults with solid tumors. Participants will be enrolled in one of 4 ascending-dose cohorts. Each treatment cycle will consist of multiple intravenous (IV) doses. Dose escalation decisions will be based on data collected during the dose-limiting toxicity (DLT) period.

Participants needed: 32
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Dicerna Pharmaceuticals, Inc., a Novo Nordisk companyUpdated: Nov 6, 2025Locations: 2
Eligibility criteria

Male or female adults, aged greater than or equal to (≥) 18 years. [+9]

Participants with known CNS or leptomeningeal metastases not controlled by prior... [+1]

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