Status: Recruiting
Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour
The efficacy of treatment with metformin for promoting cognitive recovery and brain growth in children/adolescents treated for a brain tumour will be investigated in a multi-site Phase III randomized double-blind placebo-controlled parallel arm superiority trial. Specifically, in children/adolescents aged 7 years to 21 years and 11 months who have completed treatment for a brain tumour, is oral administration of metformin for 16 weeks associated with greater improvement of cognitive function and brain growth compared to placebo administered for 16 weeks?
Participants needed: 140
Trial details
Phase: Phase 3Age: 7-21Biological sex: AllType: InterventionalSponsor: Donald MabbottUpdated: May 1, 2026Locations: 20
Eligibility criteria
medulloblastoma [+14]
Standard score of less than 60 for full scale IQ on the Wechsler Abbreviated Sca... [+14]