Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia

The purpose of this study is to evaluate the safety, tolerability and determine the recommended dose for further clinical evaluation of ELVN-001 in patients with chronic myeloid leukemia with and without T315I mutations in patients who are relapsed, refractory or intolerant to TKIs.

Participants needed: 250
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Enliven TherapeuticsUpdated: Apr 1, 2026Locations: 45
Eligibility criteria

BCR-ABL1 positive CML in chronic phase, with or without T315I mutation. [+4]

Treatment with anti-cancer or anti-CML therapy within 7 days or 5 half-lives, wh... [+2]

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Status: Recruiting

ELVN-001 for the Treatment of Chronic Myeloid Leukemia With and Without T315I Mutation in Japanese Participants

The purpose of this study is to evaluate the safety, tolerability and determine the recommended dose for further clinical evaluation of ELVN-001 in Japanese patients with chronic phase chronic myeloid leukemia with and without T315I mutations in patients who has failed, or the patient is intolerant to, or not a candidate for, at least 2 prior TKIs.

Participants needed: 21
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Enliven TherapeuticsUpdated: Jul 1, 2025Locations: 4
Eligibility criteria

BCR::ABL1 positive CP-CML that has failed, or the patient is intolerant to, or n... [+4]

Treatment with anti-cancer or anti-CML therapy within 7 days or 5 half-lives, wh... [+2]

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