Clinical trials

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Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

This is a multicenter, randomized, open-label, Phase 3 study in participants with newly diagnosed multiple myeloma to evaluate the benefits of teclistamab in combination with lenalidomide and teclistamab alone versus lenalidomide alone as maintenance therapy after autologous stem cell transplant.

Participants needed: 1,594
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: European Myeloma Network B.V.Updated: Jun 4, 2026Locations: 212
Eligibility criteria

Must have a new diagnosis of multiple myeloma according to IMWG criteria and hav... [+5]

Received any prior BCMA-directed therapy. [+5]

Status: Recruiting

A Phase II Trial of Teclistamab in Participants With Previously Treated Immunoglobulin Light-chain (AL) Amyloidosis

This is a multicenter open-label, phase 2 study in participant with previously treated immunoglobulin light-chain (AL) Amyloidosis to evaluate the benefit of teclistamab

Participants needed: 30
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: European Myeloma Network B.V.Updated: Apr 21, 2026Locations: 10
Eligibility criteria

Histologic diagnosis of AL amyloidosis and typed with immunohistochemistry/ immu... [+12]

Amyloid-specific syndrome, such as carpal tunnel syndrome or skin purpura, as th... [+7]

Status: Recruiting

Study for Frail Patients With Newly Diagnosed Multiple Myeloma Treated With Daratumumab With Teclistamab or Talquetamab.

This is a multicenter, open-label phase II study with 2 parallel cohorts for frail patients with newly diagnosed multiple myeloma treated with daratumumab in combination with teclistamab and talquetamab. The main purpose of this study is to determine the progression free survival at 18 months in patients treated with teclistamab and daratumumab (Cohort 1) or talquetamab and daratumumab (Cohort 2).

Participants needed: 150
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: European Myeloma Network B.V.Updated: Apr 15, 2026Locations: 29
Eligibility criteria

Patient is ≥18 years of age and capable of giving informed consent and must sign... [+5]

Non-secretory MM or measurable disease by urine or plasmacytoma only [+17]

Status: Recruiting

A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant

This study is researching an experimental drug called linvoseltamab. The study is focused on participants with newly diagnosed multiple myeloma (NDMM) who are ineligible for autologous stem cell transplantation (transplant-ineligible). The main purpose of this study is to compare the effect and safety of linvoseltamab with the effect and safety of the standard treatment.

Participants needed: 1,000
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: European Myeloma Network B.V.Updated: Mar 25, 2026Locations: 59
Eligibility criteria

Participants must have confirmed diagnosis of symptomatic MM per IMWG criteria. [+4]

International Myeloma Working Group Frailty Index of 2 with the exception of par... [+9]

Status: Recruiting

European Myeloma Network (EMN) Sample Project

This is an observational, non-interventional, multicenter study for the prospective collection, storage and analysis of patients' biological samples. This study establishes a common international infrastructure useful to collect standard clinical variables at baseline and during treatment and to uniformly collect and store biological samples

Participants needed: 6,000
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: European Myeloma Network B.V.Updated: Dec 3, 2025Locations: 41
Eligibility criteria

Subjects with MGUS, smouldering Multiple Myeloma (SMM) , MM (Multiple Myeloma) (... [+4]

Previous treatment with anti-myeloma therapy (excluding one course of therapy in... [+2]