Health Trials

Clinical trials

2

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Condition / disease
Location
Status: Recruiting

Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer

The study is a Phase 1b/2, multi-center, open-label, dose escalation trial evaluating the safety and preliminary efficacy of sapanisertib and serabelisib (PIKTOR) with fulvestrant and/or other anticancer therapies in participants with HR+/HER2- advanced/metastatic breast cancer.

Participants needed: 32
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Faeth TherapeuticsUpdated: Jul 2, 2026Locations: 7
Eligibility criteria

Histologically confirmed diagnosis of HR+/HER2- breast cancer. [+5]

Participants with triple-negative breast cancer. [+11]

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Status: Recruiting

Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer

This is a Phase 2, multicenter, open-label, single-arm study to evaluate the efficacy and safety of sapanisertib and serabelisib (PIKTOR) with paclitaxel in participants with advanced or recurrent endometrial cancer.

Participants needed: 40
Trial details
Phase: Phase 2Age: 18+Biological sex: FemaleType: InterventionalSponsor: Faeth TherapeuticsUpdated: Dec 24, 2025Locations: 18
Eligibility criteria

Histologically confirmed diagnosis of endometrioid endometrial carcinoma. [+6]

Participants with central nervous system metastases are not eligible, unless the... [+11]

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