Clinical trials

11

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus

Clinical trial to evaluate the safety and feasibility of corneal cross-linking in both eyes on the same day in subjects with keratoconus.

Participants needed: 15
Trial details
Phase: Phase 4Age: 13+Biological sex: AllType: InterventionalSponsor: Glaukos CorporationUpdated: Jun 5, 2026Locations: 1
Eligibility criteria

Provide written informed consent [+2]

Known allergy or sensitivity to study medications [+4]

Status: Recruiting

Travoprost Intraocular Implant + iStent Infinite

Adult subjects with elevated intraocular pressure will be randomized to receive iStent infinite trabecular bypass system plus a travoprost intraocular implant or receive a sham procedure plus a travoprost intraocular implant and be followed for 12 months.

Participants needed: 150
Trial details
Phase: Phase 4Age: 18+Biological sex: AllType: InterventionalSponsor: Glaukos CorporationUpdated: Jun 2, 2026Locations: 1
Eligibility criteria

diagnosis of open-angle glaucoma or ocular hypertension [+1]

unmedicated (washed out) IOP of >36 mmHg in the study eye [+4]

Status: Recruiting

Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Participants needed: 510
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Glaukos CorporationUpdated: Mar 30, 2026Locations: 1
Eligibility criteria

Diagnosis of Ocular Hypertension or Open-Angle Glaucoma in the study eye

Prior incisional glaucoma surgery in the study eye [+2]

Status: Recruiting

Phase 2/Phase 3 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant

Participants needed: 610
Trial details
Phase: Phase 2, Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Glaukos CorporationUpdated: Mar 2, 2026Locations: 3
Eligibility criteria

Diagnosis of open-angle glaucoma or ocular hypertension in the study eye

Prior incisional glaucoma surgery in the study eye [+2]

Status: Recruiting

Evaluation of the Safety and Efficacy of GLK-321 in Subjects With Demodex Blepharitis

This is a randomized, double-masked, placebo-controlled, dose-ranging, parallel-group, multi-center study designed to evaluate the safety and efficacy of GLK-321 in patients with Demodex blepharitis.

Participants needed: 250
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Glaukos CorporationUpdated: Feb 27, 2026Locations: 1
Eligibility criteria

Signs of Demodex blepharitis in at least one eye [+1]

Presence of eczema or dermatitis in the ocular region of either eye [+4]

Status: Recruiting

Observational Trial of the Updated Inserter for the Travoprost Intracameral Implant 75mcg

Clinical in-use observational trial to evaluate the updated inserter for the Travoprost Intracameral implant using the updated inserter (Model G2-TRIO)

Participants needed: 30
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Glaukos CorporationUpdated: Feb 27, 2026Locations: 1
Eligibility criteria

Diagnosis of Open-angle glaucoma [+1]

Subject who is breast-feeding or pregnant

Status: Recruiting

Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus

Multi-center, parallel-group, placebo-controlled trial designed to assess the safety and efficacy of twice-daily topically administered GLK-221 Ophthalmic Solution in subjects with keratoconus.

Participants needed: 100
Trial details
Phase: Phase 2Age: 18-55Biological sex: AllType: InterventionalSponsor: Glaukos CorporationUpdated: Feb 10, 2026Locations: 1
Eligibility criteria

Be ≥ 18 and ≤ 55 years of age [+1]

Pregnant, lactating or planning a pregnancy [+1]

Status: Recruiting

Safety and Efficacy of iDose® TR With Cataract Surgery vs. Cataract Surgery Alone

This trial will evaluate the safety and IOP -lowering efficacy of administering an iDose TR (travoprost intracameral implant) in conjunction with cataract surgery compared to cataract surgery alone

Participants needed: 132
Trial details
Phase: Phase 4Age: 45+Biological sex: AllType: InterventionalSponsor: Glaukos CorporationUpdated: Jan 21, 2026Locations: 1
Eligibility criteria

Cataract diagnosis: clinically significant age-related cataract eligible for pha... [+1]

Active corneal inflammation or edema. [+1]

Status: Recruiting

A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED

This study is to evaluate the safety and efficacy of NEXAGON® (lufepirsen ophthalmic gel) (NEXAGON) in subjects with persistent corneal epithelial defects (PCED). The objectives of the study are to evaluate the safety and efficacy of NEXAGON in this population.

Participants needed: 84
Trial details
Phase: Phase 2Age: 2+Biological sex: AllType: InterventionalSponsor: Glaukos CorporationUpdated: Jul 24, 2025Locations: 28
Eligibility criteria

Have a PCED that is at least 2 weeks in duration and refractory to one or more c... [+3]

Have a known ocular infection that is deemed to be active requiring therapeutic... [+9]

Status: Recruiting

Safety and Efficacy of Corneal Cross-linking in Subjects With Keratoconus

Clinical Trial to Evaluate the Safety and Efficacy of Corneal Cross-linking in Subjects with Keratoconus.

Participants needed: 150
Trial details
Phase: Phase 1, Phase 2Age: 18-55Biological sex: AllType: InterventionalSponsor: Glaukos CorporationUpdated: Jul 8, 2024Locations: 3
Eligibility criteria

Provide written informed consent [+3]

Known allergy or sensitivity to the test articles or components [+2]

Status: Recruiting

Glaukos® iStent Infinite Trabecular Micro-Bypass System in Subjects With Mild to Moderate Primary Open-angle Glaucoma

Prospective, multicenter, single-arm study of the iStent infinite in adult pseudophakic or phakic subjects with mild to moderate primary open angle glaucoma who have not failed conventional medical and surgical treatment

Participants needed: 245
Trial details
Age: 35+Biological sex: AllType: InterventionalSponsor: Glaukos CorporationUpdated: Sep 28, 2023Locations: 1
Eligibility criteria

Diagnosis of primary open-angle glaucoma [+2]

Traumatic, uveitic, neovascular, angle-closure glaucoma or [+3]