Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

EAST-1 (ERAP-inhibition in Axial Spondyloarthritis Trial - 1)

GRWD0715 is an orally administered, selective inhibitor of the Endoplasmic Reticulum Aminopeptidase 1 \[ERAP1\] enzyme being explored as a potential new treatment for axial spondyloarthritis (axSpA), a long term condition caused by inflammation predominantly affecting the sacroiliac joints (SIJs) and spine.

Participants needed: 141
Trial details
Phase: Phase 1, Phase 2Age: 18-65Biological sex: AllType: InterventionalSponsor: Grey Wolf TherapeuticsUpdated: Jun 26, 2026Locations: 16
Eligibility criteria

Healthy male and female subjects aged 18-55 years inclusive, at the Screening vi... [+16]

History or presence of any clinically significant findings in medical history, p... [+15]

Read more
Status: Recruiting

EMITT-1 (ERAP Mediated Immunopeptidome Targeting Trial - 1)

This is a Phase I/II, open-label, first-in human study of GRWD5769 alone, and in combination with another anti-cancer agent in advanced solid cancers.

Participants needed: 300
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Grey Wolf TherapeuticsUpdated: Jan 28, 2026Locations: 29
Eligibility criteria

Provision of written informed consent. [+24]

Prior therapy with an ERAP1 inhibitor. [+33]

Read more