Clinical trials

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Condition / disease
Location
Status: Not yet recruiting

Phase III, Multicenter, Randomized Controlled Clinical Study of Three-Dimensional Radiotherapy for Primary Tumors in Non-Oligometastatic Stage IV Non-Small Cell Lung Cancer

For patients with non-small cell lung cancer and more than five metastatic lesions (non-oligometastatic disease), does radical treatment of the primary lung lesion, in addition to pharmacotherapy, also provide benefits in terms of progression-free survival (PFS) and local control? Currently, there is limited clinical research on combining pharmacotherapy with radiotherapy for the primary lesion in non-oligometastatic patients. Therefore, this study aims to investigate whether radical radiotherapy targeting the primary lung lesion, in addition to pharmacotherapy, can improve local control and survival in non-oligometastatic patients, and whether the associated toxicities are acceptable.

Participants needed: 200
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Guizhou Medical UniversityUpdated: Mar 10, 2026
Eligibility criteria

Pathologically or cytologically confirmed stage IV NSCLC [9th edition, 2024]; [+6]

Stage I-III NSCLC, oligometastasis (number of metastatic lesions ≤ 5), Stage IV... [+6]

Status: Recruiting

Radiotherapy or Observation of Liver Metastases in Small Cell Lung Cancer

The aim of this randomized study is to investigate local tumor control,survival outcomes and complications on patients of liver metastasis in small cell lung cancer.

Participants needed: 66
Trial details
Age: 18-70Biological sex: AllType: InterventionalSponsor: Guizhou Medical UniversityUpdated: Jun 26, 2025Locations: 1
Eligibility criteria

Informed consent (radiation, medication) before treatment; [+9]

patients with history of mental illness; [+8]