Clinical trials

This study aims to evaluate the effects of different dietary interventions, including gluten-free, Mediterranean, and control diets, on disease activity, quality of life, and dietary inflammatory index in patients with rheumatoid arthritis. Participants will be followed for 12 weeks, and changes in clinical and nutritional outcomes will be assessed.

Study Design: Randomized Cross-Over Study Objective: This study aims to compare the acute effects of three different auditory conditions (metronome, binaural beats, and silent control) on 6-Minute Walk Test (6MWT) performance, post-exercise recovery physiology, and perceived exertion in healthy young adults. Background: Auditory-motor coupling mechanisms suggest that rhythmic auditory stimuli can lower the excitation threshold of motor neurons, thereby enhancing walking efficiency. Rhythmic stimuli such as metronomes are known to improve walking speed and coordination. Binaural beats are an auditory stimulus type generated by presenting two tones of slightly different frequencies to each ear, triggering cortical neural entrainment. It has been reported that listening to binaural beats at theta frequency following exercise increases parasympathetic activation and accelerates recovery. This study aims to examine these two auditory stimuli in comparison with a control condition in healthy young adults. Participants: Healthy young adults aged 18-35 who can walk independently and have no cardiovascular, pulmonary, neurological, or musculoskeletal conditions. Minimum sample size will be calculated using G\*Power following a pilot study, with a 20% dropout margin added. Randomization: All participants will be exposed to all three conditions on separate days. The order of application will be determined by computer-based simple randomization (randomizer.org). Six possible sequence combinations will be used to balance order effects. A washout period of at least 24 hours will be applied between sessions. Interventions: Metronome Condition: Each participant's natural walking cadence will be measured, and the metronome tempo will be set at 110% of this baseline value. Binaural Beats Condition: A carrier frequency of 120 Hz will be delivered to the right ear and 100 Hz to the left ear, generating a 20 Hz binaural beat in the Beta frequency band. Participants will listen for 6 minutes at rest immediately before the walking test. Control Condition: No auditory stimulus will be applied. The 6MWT will be conducted in all conditions along a 30-meter flat corridor in accordance with ATS/ERS standards. Measurement Time Points: Pre-test, immediately post-test, and at the 1st, 3rd, and 5th minutes of the recovery period. Outcome Measures: Primary: Total distance covered during 6MWT (meters), walking cadence (steps/min) Secondary: Heart rate, blood pressure, peripheral oxygen saturation (SpO₂), perceived dyspnea, general fatigue, and quadriceps femoris muscle fatigue assessed via the Modified Borg Scale Statistical Analysis: One-Way Repeated Measures ANOVA for walking distance and cadence; Two-Way Repeated Measures ANOVA (condition × time) for physiological parameters; Friedman test for Borg scale data; Bonferroni-corrected post-hoc tests where significant differences are found. Significance level set at p\<0.05. Study Duration: April - June 2026 (3 months)

This methodological study aims to determine the level of agreement between nurses and an artificial intelligence system (ChatGPT-4.0) in providing scenario-based discharge education for patients who have undergone coronary artery bypass graft (CABG) surgery. Thirty standardized patient scenarios representing different demographic, clinical, and psychosocial characteristics will be used. For each scenario, both expert nurses and ChatGPT-4.0 will prepare discharge education content based on six main domains and twenty-four subtopics identified from the literature and clinical guidelines. The educational materials will be independently evaluated by two blinded reviewers in terms of content accuracy, completeness, scientific consistency, and clarity of language. Agreement between nurses and AI-generated content will be analyzed using Cohen's Kappa coefficient and Fisher's Exact Test. The findings are expected to provide evidence for the reliability and applicability of AI-assisted discharge education systems in cardiac surgery nursing practice.

This randomized controlled trial will evaluate the effectiveness of artificial intelligence-supported individualized discharge education for patients undergoing coronary artery bypass graft (CABG) surgery. Participants will be assigned to either the intervention group, which will receive personalized AI-generated discharge education delivered through a nurse-avatar video in addition to standard verbal education, or the control group, which will receive standard discharge education only. The study will compare postoperative pain, anxiety, physiological stress response, recovery, and satisfaction with discharge education between the two groups. Outcomes will be measured during hospitalization and at the routine postoperative follow-up visit. The findings may help improve patient education methods and postoperative recovery in cardiac surgery patients.

The aim of this study is to evaluate the acute effects of posterior talar glide mobilisation on dorsiflexion range of motion wieght bearing (measured using the Weight-Bearing Lunge Test) and walking speed, using a randomised, sham-controlled study design.

The primary objective of our study is to compare the thickness of the masseter muscle, measured by ultrasound, in individuals with chronic neck pain to that of healthy individuals. The secondary objective of the study is to examine the relationships between masseter muscle thickness and pain intensity, neck disability level, pain catastrophizing level, and clinical diagnostic criteria in individuals with chronic neck pain.

This research is planned to examine the effect of operating room nurses' knowledge levels regarding inadvertent perioperative hypothermia (IPH) on their clinical decision-making skills. IPH is a preventable patient safety issue that can lead to serious complications such as cardiac arrhythmias, blood loss, infection, and prolonged hospital stay. The literature indicates that nurses' knowledge levels regarding IPH are generally insufficient, and this negatively impacts their clinical decision-making processes. This research is a cross-sectional study to be conducted in the operating room of Kahramanmaraş Sütçü İmam University Health Practice and Research Hospital between March 2026 and May 2026. The sample size was determined to be at least 165 nurses using power analysis. Data will be collected using a Demographic Information Form, the Inadvertent Perioperative Hypothermia Knowledge Test (IPH-BT), and a 15-item Clinical Decision-Making Scenarios Form developed by the researchers. Data will be analyzed using SPSS software; group comparisons, correlation, and multiple linear regression analyses will be performed. This study will test whether nurses' knowledge levels differ according to demographic characteristics, their relationship with clinical decision-making skills, and whether knowledge level predicts decision-making skills. This research is expected to contribute to identifying the training needs of operating room nurses regarding IPD management and strengthening their evidence-based clinical decision-making skills.

The aim of this study is to examine in detail the ultrasonographic characteristics of the vastus medialis obliquus and vastus medialis longus muscles in individuals with patellofemoral pain syndrome and to compare these findings with those of healthy individuals. It is anticipated that the results obtained will contribute to a better understanding of the muscle-based mechanisms of PFAS and provide a scientific basis for the development of muscle-specific assessment and intervention strategies in physical therapy and rehabilitation practices.

The aim of our study was to evaluate the psychometric properties of the 2-minute step test in hemophilia patients, assess its intra-rater and inter-rater reliability, and evaluate its convergent validity and construct validity supported by measurements of gait, balance, and functionality.

Patients with Parkinson's disease who apply to the Hasan Kalyoncu University Application and Research Center and meet the inclusion criteria will be included in the study. The included participants will be randomly assigned into either the intervention group or the control group using a sealed-envelope method. Both groups will undergo a standard exercise program, consisting of posture, strengthening, and balance training, under the supervision of a physiotherapist for 8 weeks, 3 days per week. In addition to this, the intervention group will receive an additional exercise program incorporating visual feedback using a laser pointer, targeting the trunk and lower extremities, also under the supervision of a physiotherapist for 8 weeks, 3 days per week.

The purpose of this study is to determine the effect of Emotional Freedom Technique (EFT) application on stress, anxiety, and sleep quality in nursing students. The nursing education process can cause high levels of psychological and physiological stress in students due to many factors such as a heavy theoretical knowledge load, clinical practice stress, exam anxiety, and shift work. This situation results in increased anxiety and impaired sleep quality, thereby negatively affecting students' academic performance, clinical skills, and overall well-being. In this context, the study aims to evaluate whether EFT, as a complementary method, is effective in reducing stress and anxiety levels in nursing students, as well as improving sleep quality. It is believed that the results of this research will contribute to the development of alternative approaches that support psychological well-being in nursing education and will provide evidence-based data on the integration of EFT into educational programs.

The aim of this study is to examine the psychometric properties of the Turkish version of the Scoliosis Caregiver Response and Emotional Scale (SCaRES) questionnaire; to evaluate the reliability of the Turkish form and to ensure its usability in clinical and research fields.

The survey examines how individuals with scoliosis define themselves and their physical appearance. Our aim in this study was to translate this survey into Turkish and demonstrate its reliability and validity.

The aim of this study was to investigate the effectiveness of myofascial release exercises performed in the late period compared to classical physiotherapy training in individuals with hand flexor tendon repair.

The aim of our study is to investigate the effects of emicizumab treatment on the musculoskeletal system in children with hemophilia A.

Our study is unique in that it utilizes a self-designed fascial mobilization protocol and ultrasonographic evaluation for adhesive capsulitis. Therefore, the aim of our study is to investigate the effects of fascial therapy on pain, normal joint range of motion, proprioception, and fascial architecture in patients diagnosed with adhesive capsulitis.

Our study aims to investigate the effects of exercise training on pain, range of motion, functionality and shoulder architecture in patients with adhesive capsulitis.

This study aims to explore the effects of augmented reality (AR)-supported physiotherapy on body awareness, motivation, and exercise adherence in adolescents diagnosed with Adolescent Idiopathic Scoliosis (AIS). Using a qualitative phenomenological approach, the study will involve semi-structured interviews with adolescents who have completed at least four weeks of AR-based physiotherapeutic scoliosis-specific exercises. The goal is to understand participants' lived experiences with AR-enhanced rehabilitation and to inform the development of adolescent-centered, technology-integrated physiotherapy strategies in conservative scoliosis care.

The research is planned as a randomised controlled experimental study. Research data will be collected between March-July 2025. The population of the study will consist of all pregnant women who come to Kilis Prof.Dr.Alaeddin Yavaşca State Hospital Gynaecology and Obstetrics Polyclinics. The sample of the study will consist of primiparous pregnant women who meet the research criteria and accept to participate in the study among the pregnant women who come to Kilis Prof.Dr.Alaeddin Yavaşca State Hospital Gynaecology and Obstetrics Polyclinics. Data will be collected from primiparous pregnant women who meet the inclusion criteria and accept the study after being informed about the study by meeting the pregnant women who come to Kilis Prof.Dr.Alaeddin Yavaşca State Hospital Gynaecology and Obstetrics Outpatient Clinic before or after their outpatient examinations. Data Collection Tools Personal Information Form, Wijma Birth Anticipation / Experience Scale A Version scale and Prenatal Self-Assessment Scale Dependent variables of the study: Wijma Birth Expectancy / Experience Questionnaire (W-DEQ) A Version and Prenatal Self-Assessment Scale subscales of acceptance of maternal role and readiness for childbirth scales. Independent variables of the study: Socio-demographic and obstetric characteristics of primiparous pregnant women

This descriptive study aims to examine the relationship between self-efficacy and medication adherence in individuals with coronary artery disease (CAD). The study will be conducted between March and October 2025 at Adıyaman University Training and Research Hospital with a planned sample size of 135 participants. Data will be collected using a Descriptive Information Form, the Self-Efficacy for Managing Chronic Disease Scale, and the Medication Adherence Report Scale (MARS).

It is aimed to minimise both unplanned extubation and skin damage with the surgical incision drep that we will use to fix the endotracheal tube in neonatal preterm infants and to reduce the complications that may develop due to these events. In addition, it is aimed to evaluate the relationship between these parameters by using devices measuring skin moisture, skin pH and Neonatal Skin Condition Assessment Scale in experimental and control groups.

Dysmenorrhea is severe lower abdominal pain in women during menstruation. The pain is usually cramping and can radiate to the thighs or lower spine. Lower abdominal pain may be accompanied by vomiting, headache, back pain, diarrhea, fatigue, etc. Depending on the pathophysiology, dysmenorrhea is classified into two types: primary and secondary. Primary dysmenorrhea (PD) is menstrual pain associated with normal ovulatory cycles in the absence of pelvic pathology and a clear physiologic etiology and is most commonly seen in adolescents and young adults. There are numerous studies on PD in the literature, but there is still a lack of studies on which of the non-pharmacologically recommended exercise and other methods is more effective on dysmenorrhea symptoms, sleep and quality of life for individuals with this problem. Different exercise intensities may affect PD symptoms through different mechanisms. Moderate to high intensity exercise may reduce pain by increasing anti-inflammatory cytokines, whereas less intense exercise, such as yoga, affects pain levels by decreasing cortisol levels. The lack of research on which exercise training is more effective in PD individuals was considered as a limitation. In the light of this information, the aim of the investigators study is to compare the effects of different training techniques on dysmenorrhea symptoms, sleep and quality of life in PD treatment and to present the preferability of these techniques based on evidence.

The aim of this observational study was to examine the effect of Mindfulness-Based Stress Reduction Program on Smartphone Addiction, Stress and Quality of Life in Nursing Students. The main question it aims to answer is: Is there a significant relationship between smartphone addiction, quality of life and stress in nursing students? Smartphone addiction scale will be applied and students with risky scores will be determined and pre-test will be applied to the students in the experimental group according to randomization. During an 8-week intervention period, in addition to mindfulness practices and experiential studies, experiential practices will be carried out on stress, stress management and how mindfulness is applied in daily life and interpersonal communication through the sharing of the participants.

This article discusses the prevalence and health implications of constipation in the elderly population. Health problems increase with age and negatively affect quality of life. Constipation is a common problem in the elderly that severely reduces quality of life and is associated with many factors. Pharmacologic and non-pharmacologic methods are used for the management of constipation, but long-term use of pharmacologic treatments may lead to adverse effects. Therefore, non-pharmacologic approaches are gaining more importance. In this context, Su Jok therapy, as an oriental medicine method, is a treatment method that aims to affect various organs of the body by using reflection points on the hands and feet. It is argued that Su Jok therapy can be beneficial in terms of symptom management and improving quality of life, especially in fields such as nursing and midwifery. In Turkey, there are no studies examining the effect of Su Jok therapy on constipation symptoms. This project aims to determine the effect of Su Jok therapy on constipation symptoms and quality of life, and the results are expected to contribute to the development of health services and treatment methods

The aim of this study is to examine and compare the bladder and bowel functions, activation of pelvic floor and abdominal muscle groups and quality of life of children diagnosed with spina bifida who did not receive any treatment due to bladder-intestinal dysfunction, received only urotherapy training and received biofeedback training combined with breathing. The type of study is clinical trial. Question 1: Does biofeedback training combined with breathing have an effect on bladder and bowel functions, activation of pelvic floor and abdominal muscle groups and quality of life in spina bifida patients with neurogenic bladder and bowel disorders? Question 2: Does urotherapy training have an effect on bladder and bowel functions, activation of pelvic floor and abdominal muscle groups and quality of life in spina bifida patients with neurogenic bladder and bowel disorders? Group 1: control group Group 2: urotherapy training group Group 3: Biofeedback exercise training group combined with breathing There will be no extra treatment to group 1. Urotherapy Training: Standard urotherapy is a combined method that includes clinical assessment (recording voiding frequencies, voiding volumes and incontinence episodes in a bladder diary), voiding habit training, behavior modification instructions, lifestyle recommendations regarding fluid intake and supporting children and their parents through the process. Exercise Training: Urotherapy training will be given at the beginning of the treatment process. Contraction and relaxation will be applied around the external sphincter in combination with diaphragmatic breathing by visual imagery with EMG biofeedback application. Group 1, group 2 and group 3 will be compared.