Health Trials

Clinical trials

4

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Assessment of CCM in HF With Higher Ejection Fraction

The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.

Participants needed: 1,500
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Impulse DynamicsUpdated: Jun 26, 2026Locations: 105
Eligibility criteria

Signed and dated informed consent form; [+6]

Resting ventricular rate <50 or >110 bpm; [+21]

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Status: Recruiting

CCM OPEN HF Registry

The registry has been designed to evaluate the long-term safety and efficacy of CCM therapy in a real-world setting.

Participants needed: 5,500
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Impulse DynamicsUpdated: Apr 23, 2026Locations: 28Duration: 5 Years
Eligibility criteria

Patients who have /will be implanted with Impulse Dynamics CCM technologies (e.g... [+1]

Noncompliant patients (e.g. for follow-up visits, medication, etc.) as determine... [+1]

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Status: Recruiting

Propensity-Matched Study of Cardiac Contractility Modulation Therapy in Heart Failure

The purpose of this prospective, multi-center, propensity-matched coverage with evidence development (CED) study is to assess the impact of cardiac contractility modulation (CCM) on mortality and heart failure hospitalizations in Medicare-eligible patients with heart failure who meet indications for CCM.

Participants needed: 4,200
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Impulse DynamicsUpdated: Mar 24, 2026Locations: 1
Eligibility criteria

Continuous representation in the database in the year prior to index. [+5]

Subject has had a prior heart transplant [+2]

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Status: Recruiting

CCM and Implementation of Guideline-Directed Medical Therapy in Patients With Heart Failure (Fix-GDMT-HF)

The primary objective of this study is to evaluate the impact of Cardiac Contractility Modulation (CCM) therapy on the initiation and up-titration of Guideline-Directed Medical Therapy (GDMT) in patients with heart failure (HF). This will be assessed by the change in Quad Medication Score (QMS) from baseline (pre-CCM) to 6-month following post-CCM device implant.

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Impulse DynamicsUpdated: Jul 11, 2025Locations: 2
Eligibility criteria

Adults (≥18 years) diagnosed with symptomatic heart failure [+3]

Patients that are unlikely to adhere to medical therapy for reasons other than i... [+7]

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