Clinical trials

2

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Condition / disease
Location
Status: Recruiting

Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

This is a Phase 1/1b, nonrandomized, open-label, parallel assignment, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of azer-cel, an allogeneic anti-CD19 CAR T, in adults with r/r B ALL, r/r B-cell NHL and CLL/SLL.

Participants needed: 135
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Imugene LimitedUpdated: Feb 2, 2026Locations: 23
Eligibility criteria

Diffuse large B-cell lymphoma (DLBCL) including Richter's transformation [+23]

Requirement for urgent therapy due to tumor mass effects such as bowel obstructi... [+17]

Status: Recruiting

Long-term Follow-up of Study Participants Who Received an Allogeneic Chimeric Antigen Receptor T-Cell Product in an Imugene Ltd. Clinical Study

The goal of this observational study is to collect information on the long-term safety of study participants who received an Allogeneic Chimeric Antigen Receptor (CAR) T-Cell Product in an Imugene Clinical Study. The main questions it aims to answer are: * What are the frequency, severity, duration, and outcome of clinically significant Clinical Events of Interest (CEI)? * What is the duration of response and overall survival time after taking an allogeneic CAR T-Cell product on an Imugene clinical study? Participants will have a yearly visit either face to face or remotely for up to 15 years to check for CEI.

Participants needed: 75
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Imugene LimitedUpdated: May 14, 2025Locations: 1
Eligibility criteria

Receipt of at least 1 dose of azer-cel in an Imugene clinical study. [+2]

No unique exclusion criteria apply to this study.