Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

A Phase I study to evaluate the safety of a novel, orally available, selective, and potent small molecule inhibitor of the histone lysine methyl transferase MMSET (also known as NSD2/WHSC1) to prevent the dimethylation of H3K36 in adult patients with relapsed or refractory multiple myeloma (RRMM).

Participants needed: 165
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: K36 Therapeutics, Inc.Updated: Jun 8, 2026Locations: 22
Eligibility criteria

≥ 18 years of age [+10]

Patients in Cohorts B1 and B2 must not have received prior mezigdomide treatment [+15]

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Status: Recruiting

A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)

Study K36-MCRPC-001 is the first in human clinical trial testing KTX-2001 alone and with darolutamide in men with metastatic castration-resistant prostate cancer. The study aims to assess whether the drug is safe, increasing doses alone and in combination with darolutamide, whether it is effective in treating metastatic castration-resistant prostate cancer, and measuring how the drug(s) behaves in the body.

Participants needed: 144
Trial details
Phase: Phase 1Age: 18+Biological sex: MaleType: InterventionalSponsor: K36 Therapeutics, Inc.Updated: Mar 23, 2026Locations: 13
Eligibility criteria

Age ≥18 years. [+8]

Presence of symptomatic or uncontrolled brain metastases unless adequately treat... [+17]

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