Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS

This is a single-arm pilot study of the feasibility and safety of metformin in patients with clonal cytopenia of undetermined significance (CCUS) or lower-risk myelodysplastic neoplasms (LR-MDS).

Participants needed: 40
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Kirsten GrønbækUpdated: Nov 22, 2024Locations: 1
Eligibility criteria

LR-MDS according to the revised international prognostic scoring system (IPSS-R)... [+6]

Any prior treatment with metformin [+15]

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Status: Recruiting

Combining Active and Passive DNA Hypomethylation

This is a multicentre, randomized, parallel-group, placebo-controlled, double-blind phase 2 study of the efficacy and safety of oral vitamin C supplement in combination with azacitidine in patients with higher-risk MDS, CMML-2 or low-blast count AML. The primary purpose is to investigate if oral vitamin C supplementation to azacitidine, compared with azacitidine + placebo, can increase the effectiveness of epigenetic therapy in patients with higher-risk myeloid malignancies, who are not candidates for allogeneic hematopoietic stem cell transplantation.

Participants needed: 196
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Kirsten GrønbækUpdated: Apr 17, 2024Locations: 10
Eligibility criteria

MDS Higher-risk MDS according to the IPSS-R, i.e., intermediate- to very high-ri... [+2]

Patient eligible for allogeneic stem cell transplantation [+12]

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