Status: Not yet recruiting
Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia
Cognitive impairment is a major determinant of disability in schizophrenia. Aerobic exercise improves global cognition in schizophrenia, particularly working memory and attention/vigilance. Transcranial direct current stimulation (tDCS) targeting frontal regions has shown promise for cognitive deficits, including working memory improvements in some studies. This randomized 2×2 factorial trial will test the independent and combined effects of supervised aerobic exercise and prefrontal tDCS on cognition in treatment resistant schizophrenia, measured using the MATRICS Consensus Cognitive Battery (MCCB).
Participants needed: 160
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: Kit Wa ChanUpdated: Feb 11, 2026Locations: 1
Eligibility criteria
DSM 5 schizophrenia-spectrum disorders [+3]
Neurological disorder (e.g., epilepsy, stroke) or significant head injury [+4]