Health Trials

Clinical trials

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Condition / disease
Location
Status: Recruiting

A PHASE II PROSPECTIVE RANDOMIZED DOUBLE-MASKED CONTROLLED STUDY ASSESSING THE SAFETY & EFFICACY OF RHPRG4 (450 µG/ML RECOMBINANT HUMAN PROTEOGLYCAN 4) COMPARED TO VEHICLE FOR THE TREATMENT OF SJÖGREN'S RELATED DRY EYE DISEASE

rhPRG4-Sjögren's-002 is a prospective multi-center study conducted in Australia to evaluate the safety and efficacy of topically-applied rhPRG4 in subjects with Sjögren's related Dry Eye Disease.

Participants needed: 80
Trial details
Phase: Phase 2Age: 18-80Biological sex: AllType: InterventionalSponsor: Lubris Bio Pty LtdUpdated: Jun 22, 2026Locations: 6
Eligibility criteria

Have the ability to comprehend and provide a signed and dated consent form. [+9]

Are currently or have a history of any ocular or systemic disorder or condition... [+20]

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Status: Recruiting

A PHASE II PROSPECTIVE RANDOMIZED DOUBLE-MASKED CROSSOVER STUDY ASSESSING THE SAFETY & EFFICACY OF RHPRG4 (450 μG/ML RECOMBINANT HUMAN PROTEOGLYCAN 4) COMPARED TO VEHICLE FOR THE TREATMENT OF OCULAR GRAFT-VERSUS-HOST DISEASE (OGVHD)

An 84-day, prospective, randomized (1:1) vehicle controlled, double-masked pre-market, crossover study. Subjects with moderate to severe oGVHD related Dry Eye Disease Each subject will receive both treatments in random sequence, each for 28 days, separated by a 14-day vehicle washout period.

Participants needed: 15
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Lubris Bio Pty LtdUpdated: Jan 20, 2026Locations: 3
Eligibility criteria

Have the ability to comprehend and provide a signed and dated consent form. [+9]

are currently pregnant or, [+4]

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