Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Oral Pooled Fecal Microbiotherapy to Prevent Allogeneic Hematopoietic Cell Transplantation Complications (PHOEBUS Trial)

This randomized, placebo-controlled phase IIb study (PHOEBUS trial) aims to evaluate the activity of fecal microbiotherapy MaaT033 to improve survival through the prevention of transplant-related complications in eligible alloHCT patients

Participants needed: 387
Trial details
Phase: Phase 2Age: 50+Biological sex: AllType: InterventionalSponsor: MaaT PharmaUpdated: Dec 27, 2024Locations: 54
Eligibility criteria

Age ≥ 50 years old [+6]

Patients planned to receive a non-myeloablative conditioning regimen (2 Gray tot... [+20]

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Status: Available

Early Access Program With MaaT013 in Steroid-refractory Acute Gastrointestinal Graft Versus Host Disease

MaaT013 is still in clinical development phase and is not approved yet for marketing in any region. During the development program, MaaT Pharma has undertaken initial development with closely related product candidates, leading to the Phase II HERACLES study in which MaaT013 preliminary safety and efficacy were assessed in the context of steroid-resistant, gastrointestinal aGraft versus Host Disease (SR-GI-aGvHD). In addition, a pivotal Phase III study (ARES trial) is planned. In the absence of medical options in patients with gastrointestinal acute GvHD refractory to multiple lines of treatment, this early access program has been implemented.

Trial details
Age: 18+Biological sex: AllType: Expanded AccessSponsor: MaaT PharmaUpdated: Aug 28, 2024Locations: 46
Eligibility criteria

Age > or = 18 [+3]

Active uncontrolled infection [+8]

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