Status: Not yet recruiting
Evaluation of Neoadjuvant Stereotactic Radiosurgery (SRS) and Multi-fraction SRS Alone for the Treatment of Large Brain Metastases
The prospective, two-arm, randomized, controlled, multicentric phase III RENESANS trial is designed to compare the efficacy and safety of neoadjuvant stereotactic radiosurgery (Neo-SRS) versus multi-fraction stereotactic radiosurgery (mfSRS) in patients with large brain metastases, with the primary objective of evaluating the incidence of central nervous system composite events.
Participants needed: 98
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Maciej HaratUpdated: Jan 9, 2026
Eligibility criteria
Age ≥18 years. [+13]
No resectable lesion ≥2.5 cm. [+9]