Clinical trials

6

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

CC-97540 in Patients With Antineutrophil Cytoplasmic Antibody-associated Vasculitis

The purpose of this study is to evaluate the safety of CC-97540 in relapsed or refractory severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

Participants needed: 12
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Marcela V. Maus, M.D.,Ph.D.Updated: May 15, 2026Locations: 1
Eligibility criteria

Able to voluntarily provide written informed consent prior to the performance of... [+17]

Current or historical positivity for a glomerular basement membrane antibody. [+15]

Status: Recruiting

TriPRIL CAR T Cells in Multiple Myeloma

This research study involves the study of TriPRIL CAR T Cells for treating people with relapsed or refractory multiple myeloma and to understand the side effects when treated with TriPRIL CAR T Cells. This research study involves the study drugs:. * TriPRIL CAR T Cells * Fludarabine and Cyclophosphamide: Standardly used chemotherapy drugs as part of lymphodepleting process

Participants needed: 18
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Marcela V. Maus, M.D.,Ph.D.Updated: May 12, 2026Locations: 1
Eligibility criteria

Ability to understand and the willingness to sign a written informed consent doc... [+24]

Any prior systemic treatment for multiple myeloma within the 14 days prior to sc... [+29]

Status: Recruiting

CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

This research study involves the study of CD79b-19 CAR T cells for treating people with relapsed/refractory Non-Hodgkin Lymphoma and to understand the side effects when treated with CD79b-19 CAR T cells. This research study involves the study drugs: * CD79b-19 CAR T cells * Fludarabine and Cyclophosphamide: Standardly used chemotherapy drugs as part of lymphodepleting process

Participants needed: 24
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Marcela V. Maus, M.D.,Ph.D.Updated: Mar 16, 2026Locations: 1
Eligibility criteria

Voluntarily sign informed consent form(s) [+25]

Treatment with an any investigational cellular therapy within 8 weeks prior to a... [+15]

Status: Recruiting

Long-term Follow-up of Subjects Treated With CAR T Cells

This is a single site, non-randomized, open-label, long-term safety and efficacy follow-up study for Phase 1 studies that evaluate the safety and efficacy of CAR T cells: NCT05660369 (DF/HCC# 22-175) and NCT06026319 (DF/HCC# 23-474).

Participants needed: 45
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Marcela V. Maus, M.D.,Ph.D.Updated: Mar 16, 2026Locations: 1
Eligibility criteria

Provision of voluntary written informed consent by subject [+1]

Status: Recruiting

CARv3-TEAM-E T Cells in Glioblastoma

The goal of this research study is to determine the best dose of CARv3-TEAM-E T Cells for treating participants with glioblastoma. The name of the treatment intervention used in this research study is: -CARv3-TEAM-E T Cells (or Autologous T lymphocytes).

Participants needed: 21
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Marcela V. Maus, M.D.,Ph.D.Updated: Feb 4, 2026Locations: 1
Eligibility criteria

Safety Run In Arm and ARM 1: Recurrent GBM, EGFRvIII mutant [+31]

Intraparenchymal posterior fossa disease [+17]

Status: Recruiting

Emapalumab Prevention of CAR-T Cell Associated Toxicities

This research study involves assessing the impact of emapalumab as preventative management of CAR-T related cytokine release syndrome in participants with Non-Hodgkin's lymphoma (NHL). The research study involves the following study interventions: * Fludarabine and cyclophosphamide (Lymphodepleting Chemotherapy) * Axicabtagene Ciloleucel * Emapalumab

Participants needed: 28
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Marcela V. Maus, M.D.,Ph.D.Updated: Nov 14, 2025Locations: 2
Eligibility criteria

Adult patients with large B-cell lymphoma that is refractory to first-line chemo... [+15]

History of malignancy other than nonmelanoma skin cancer or carcinoma in situ (e... [+19]