Clinical trials

26

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Evaluation of Hepato-Pancreato-Biliary

Some reports cite over 80% of surgery residency graduates are seeking additional training to improve on their experiences to be ready for practice. The Fellowship Council created several fellowship tracts including HPB (Hepato-Pancreato-Biliary),Advanced GI (gastrointestinal) and Minimally Invasive surgery to address this issue, and bridge the gap in training between residency and real life practice in those that seek a practice in HPB or complex GI surgery, respectively. By the end of fellowship, the core goal is to make the graduating fellows ready for independent practice in HPB or complex GI surgery cases.

Participants needed: 100
Trial details
Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Jun 10, 2026Locations: 1
Eligibility criteria

Current, and past fellows of Fellowship Council(FC )sponsored fellowship includi... [+1]

Status: Recruiting

Advanced GastroInstestinal(GI) Surgery Training in Residency and Fellowship.

The aim of this anonymous survey is to identify who teaches GI procedures to general surgical residents during residency training and understand the need as well as desire for an Advanced Surgical GI fellowship amongst senior surgical residents. We also hope to identify the self-reported level of comfort of senior general surgery residents in completing both common and complex GI procedures.

Participants needed: 260
Trial details
Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Jun 10, 2026Locations: 1
Eligibility criteria

Not listed

Status: Recruiting

Enteric Anastomoses

This retrospective data repository will serve as a means to aggregate and analyze best practices as relative to traumatic colon injury outcomes.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Jun 10, 2026Locations: 1Duration: 5 Years
Eligibility criteria

Not listed

Status: Recruiting

Dual Antiplatelet Therapy (DAPT) in Patients With Baseline Thrombocytopenia

The use of clopidogrel as part of DAPT will be associated with lower bleeding rates compared to ticagrelor in patients with chronic thrombocytopenia requiring Percutaneous intervention (PCI )with Drug Eluting Stent (DES) or Bare Metal Stint(BMS).

Participants needed: 300
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Jun 10, 2026Locations: 1
Eligibility criteria

≥ 18 years [+3]

Death within 48 hours post-PCI [+1]

Status: Recruiting

PK(Pharmacokinetic) Papyrus Covered Coronary Stent System

The PK Papyrus Covered Coronary Stent System is a coronary stent being used at Methodist Dallas Medical Center for patients with coronary perforations.

Participants needed: 41
Trial details
Biological sex: AllType: InterventionalSponsor: Methodist Health SystemUpdated: Jun 10, 2026Locations: 1
Eligibility criteria

Patients with acute perforations of native coronary arteries and coronary bypass...

Patients in whom antiplatelet agents or anticoagulation therapy is contraindicat... [+6]

Status: Recruiting

Peroral Endoscopic Myotomy for the Treatment of Achalasia

There will be a retrospective chart review for patients who underwent endoscopic procedures and POEM from 06/2016 - 01/2019 \& a prospective chart review will be performed for patients who will undergo endoscopic procedures and POEM from 02/2019 - 06/2021

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Jun 10, 2026Locations: 1
Eligibility criteria

Any discharged patient who has undergone clinically indicated and/or standard of... [+1]

Any patient who has not undergone POEM for the treatment of Achalasia. [+1]

Status: Recruiting

Evaluation of Outcomes From Treatment of Benign or Malignant Pancreatic Diseases

This study will be a retrospective chart review of patients who have been diagnosed with the benign or malignant pancreatic disease under the practice of Dr. Rohan Jeyarajah, M.D., Dr. Houssam Osman M.D., and Dr. Edward Cho M.D., Sc.M. at Methodist Health System Hospital in Richardson, Texas(TX). The investigators plan to conduct an analysis of patients meeting the inclusion criteria from 2005 to present. Study will also be conducted by the PI, Sub-Is, surgery fellows, office staff and clinical research coordinator who are delegated to do by the PI. Data will be obtained by looking through either investigator's patients or through a national database. Data will be analyzed primarily by the study conductors.

Participants needed: 500
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Jun 10, 2026Locations: 1
Eligibility criteria

• All patients diagnosed and treated for pancreatic diseases, benign or malignan... [+1]

• Patients that are not diagnosed with or treated for pancreatic diseases [+1]

Status: Recruiting

Exploratory Analysis of Enhanced Liver Function (ELF) Test to Detect Early Fatty Liver in High Risk Population

In this initial investigator-initiated retrospective study, aim to analyze the enhanced liver fibrosis (ELF) scores in this high-risk population for NAFLD/nonalcoholic steatohepatitis(NASH)-related fibrosis. Study define 'high-risk' to include metabolic syndrome, which can be further defined by an atherosclerotic cardiovascular disease (ASCVD) score \>7.5, any diagnosis of hyperlipidemia, history of coronary artery disease, history of heart failure, hypertension and/or type 2 diabetes. Study would also like to compare the performance of this score with historical methods of fibrosis assessment, where applicable, including vibration-controlled transient elastography, magnetic resonance elastography, blood markers and liver biopsy. Study will assess the impact of ELF scores on predicting liver events in the time, have used it and determine if diet, lifestyle changes and/or pharmacotherapy will improve serial ELF scores. Will also seek to understand how ELF scores are distributed in our community.

Participants needed: 300
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: May 13, 2026Locations: 1
Eligibility criteria

Age: ≥ 18 years [+1]

Patients with incomplete data and those lost to follow up.

Status: Recruiting

Early-Onset Colorectal Cancer Patients Too Young for Screening

This is a population-based retrospective study using the Surveillance, Epidemiology, and End Results (SEER) registry and National Cancer Data Base (NCDB) to look at colorectal cancer (CRC) patients younger than 35 and comparing them against CRC patients older than 35 years of age.

Participants needed: 100
Trial details
Age: 35+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Apr 30, 2026Locations: 1
Eligibility criteria

Colorectal cancer

No Colorectal cancer

Status: Recruiting

A Retrospective Analysis of Outcomes in Patients With Hepatorenal Syndrome at Methodist Dallas Medical Center

Hepatorenal syndrome (HRS) is a common cause of acute kidney injury (AKI) in patients with liver disease \[1\]. Increased activity and presence of vasodilators such as nitric oxide in cirrhotic patients leads to vasodilation, especially in the splanchnic circulation, resulting in hemodynamic changes that precipitate renal injury \[1\]. Patients may present with elevated serum creatinine (Cr), benign urine sediment, and low urine sodium \[1\].

Participants needed: 500
Trial details
Age: 18-85Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: May 1, 2026Locations: 1
Eligibility criteria

Presence of cirrhosis, acute liver failure, or acute-on-chronic liver failure [+6]

1. HRS-AKI patients <18 years of age 2. All patients hospitalized between April...

Status: Recruiting

Traumatic Cardiac Arrest

This retrospective data repository will serve as a means to aggregate and analyze order of pre-hospital care (intubation, medication, etc) as it relates to Traumatic cardiac arrest.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Mar 24, 2026Locations: 1Duration: 5 Years
Eligibility criteria

Not listed

Status: Recruiting

Cardiac Clearance vs G60 Hip Frailty Index

The primary objective of this study is to establish a data repository that will be permissive of quality improvement studies/observations specific to postoperative mortality outcomes for geriatric patients with orthopedic injuries based on Orthopedic Hip Frailty Score and preoperative cardiac clearance predictors.

Participants needed: 100
Trial details
Age: 60+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Mar 24, 2026Locations: 1
Eligibility criteria

Not listed

Status: Recruiting

Acute Subdural Hematoma

This retrospective data repository will serve as a means to aggregate and analyze standard surgical interventions and Middle Meningeal Arteryembolization as suitable treatment options for Acute Subdural Hematoma.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Mar 24, 2026Locations: 1
Eligibility criteria

≥18 years old [+2]

<18 years old [+1]

Status: Recruiting

Trauma Activation Criteria

To quantify the over- and under-triage rates as relative to trauma activation criteria reform.

Participants needed: 5,000
Trial details
Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Mar 24, 2026Locations: 1
Eligibility criteria

Not listed

Status: Recruiting

Evaluation of Emergency Medicine Pharmacist Impact on Blood Culture Review Following Emergency Department Discharge

Patients are commonly discharged from the Emergency Department(ED) with pending blood culture results. Blood cultures can take up to 48 hours to become positive which is why it is important to notify patients with true positive cultures as soon as possible. Delay in notification can lead to other serious complications such as sepsis, septic shock, and death. The American College of Emergency Physicians states pharmacists serve a critical role in ensuring efficient, safe, and effective medication use in the ED and advocates for health systems to support dedicated roles for pharmacists within the ED. Pharmacists help to decrease the workload on the healthcare team, especially in the ED where there is high volume and acuity.Emergency medicine pharmacist (EMP) play a significant role in the optimization of therapy, medication safety, and reducing costs. There is strong evidence for the positive impact EMPs have on microbiological culture review. Overall, pharmacist review of late cultures results in higher rates of appropriate antimicrobial therapy and decreased missed interventions.These prior studies focused on the review of microbiological tests, including sexually transmitted infections, urine, and wound cultures; however, there was limited data to support the role of pharmacists evaluating late blood culture results.

Participants needed: 126
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Mar 20, 2026Locations: 1Duration: 6 Months
Eligibility criteria

Patients with a positive blood culture result, collected during the initial ED v...

Patients admitted to inpatient and patients transferred from ED to another acute...

Status: Recruiting

Endoscopic Retrograde Cholangiopancreatography

The risk of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP) is influenced by patient and procedure-related factors. Strategies to decrease PEP(Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis) are of great importance.

Participants needed: 100
Trial details
Age: 15+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Mar 24, 2026Locations: 1Duration: 25 Years
Eligibility criteria

Not listed

Status: Recruiting

Volume Outcome Relationships and Effects

This is a retrospective analysis to assess if high-volume hospital facilities experience greater or lesser rates of incidence in patients with esophageal cancer than low-volume facilities.

Participants needed: 30
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Mar 20, 2026Locations: 1
Eligibility criteria

esophageal cancer

No esophageal cancer

Status: Recruiting

Leadership Training Affect Physician Career Satisfaction

The aim of the study is to evaluate the impact of organizational interventions for physician development on wellbeing, and investigate wellbeing and other characteristics of physicians with and without formal leadership roles.

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Methodist Health SystemUpdated: Mar 20, 2026Locations: 1
Eligibility criteria

Age: ≥18 years [+3]

<18 years of age [+3]

Status: Recruiting

Evaluation of Resection Techniques for Pancreatic Tumors

The objective of this study is to compare open and minimally invasive pancreatic and liver resection techniques and analyze the different outcome variables from the clinical standpoint. The plan is to investigate patient survival, length of stay, complication rates, operative time, transfusion rate, 30 and 90-day readmission rate, and hospital charges.

Participants needed: 431
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Mar 20, 2026Locations: 1
Eligibility criteria

Patients that have undergone pancreatic or liver resection surgeries from Januar... [+1]

Patients that have not undergone pancreatic resection surgeries [+1]

Status: Recruiting

Peptide Receptor Radionuclide Therapy (PRRT) for the Treatment of Neuroendocrine Tumors

The specific aim is of this study is to gain a better understanding of the patient characteristics, treatment responses, survival outcomes, and adverse events associated with PRRT in patients with gastroenteropancreatic primary NETs.

Participants needed: 50
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Mar 20, 2026Locations: 2
Eligibility criteria

> 18 years of age [+13]

Do not meet the Study Inclusion Criteria laid out in section 6.3

Status: Not yet recruiting

Monitoring the Response of Combination Ursodiol and Seladelpar Treatment

This study aims to provide comprehensive insights into the therapeutic effects of combination treatment with ursodiol and seladelpar in PBC patients by assessing biochemical responses using biomarkers such as ALP and total bilirubin.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Aug 14, 2025
Eligibility criteria

Patients must have a confirmed diagnosis PBC as per established diagnostic crite... [+4]

Patients that do not meet inclusion criteria. [+6]

Status: Recruiting

Community-based Partnership's Efficacy in Decreasing Injury Rates At Night in Dallas, TX

According to the Centers for Disease Control and Prevention (CDC), "88,000 people die every year due to alcohol-related issues including homicide, sexual assault, intimate partner violence, and suicide". In the city of Dallas, violent crimes have decreased by roughly 4% in 2022 compared to 2021. Dallas Police Department (DPD) implemented changes in May 2021 to combat violent crimes.

Participants needed: 500
Trial details
Age: 18-85Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Nov 19, 2024Locations: 1
Eligibility criteria

• Chief complaint or diagnosis associated with a trauma mechanism of injury: ass... [+2]

• Injuries from mechanism other than assault, MVC, MCC, or auto-ped/bicycle [+2]

Status: Recruiting

Evidence-based Approach to Reduce Falls in Adult Patients

The project aims to promote patient safety and quality care by reducing preventable falls and falls with injuries using an evidence-based solution.

Participants needed: 1,000
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Nov 20, 2024Locations: 1
Eligibility criteria

Adult (≥18 years) inpatients admitted for various medical-surgical conditions in...

Patients with psychiatric conditions and cognitive impairments will be excluded...

Status: Recruiting

Validation of COMPAT-SF Spanish Translation

Prospective translation validation pilot study that will collect data from Spanish-speaking CP patients seen at Methodist Dallas Medical Center (MDMC) beginning June 2024 through July 2027, in order to validate a Spanish-translated COMPAT-SF instrument.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Methodist Health SystemUpdated: Nov 20, 2024Locations: 1
Eligibility criteria

18 years or older in age [+4]

Subjects who do not meet the criteria in section 4.1