Health Trials

Clinical trials

2

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Condition / disease
Location
Status: Recruiting

A Phase I Study of SIM0505 in Participants With Advanced Solid Tumors

This is an open-label, multicenter phase 1 study to evaluate the safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of SIM0505 in Adult Participants with Advanced Solid Tumors

Participants needed: 414
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: NextCure, Inc.Updated: Jan 29, 2026Locations: 17
Eligibility criteria

Written informed consent is obtained prior to any procedures that are not consid... [+7]

For Part 2: has clear cell, mucinous or sarcomatous histology, mixed tumors cont... [+8]

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Status: Recruiting

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

This is an open-label, phase 1, dose escalation and dose expansion study to determine safety and tolerability, and to determine the maximum tolerated dose and / or recommended phase 2 dose of LNCB74 in participants with advanced solid tumors.

Participants needed: 145
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: NextCure, Inc.Updated: Dec 16, 2025Locations: 14
Eligibility criteria

The participant provides written informed consent [+10]

A WOCBP who has a positive serum pregnancy test (within 72 hours) prior to treat... [+29]

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