Clinical trials

8

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Study of NM8074 in Patients With Immunoglobulin A Nephropathy (IgAN)

This is a Phase II, open-label study designed to To evaluate the safety and efficacy of NM8074 in reducing proteinuria relative to baseline in IgAN patients after 99 days of treatment.

Participants needed: 10
Trial details
Phase: Phase 2Age: 18-65Biological sex: AllType: InterventionalSponsor: NovelMed TherapeuticsUpdated: Apr 13, 2026
Eligibility criteria

Male and female patients ≥18 years of age at the time of consent. [+5]

Evidence of severe urinary obstruction or difficulty in voiding; any urinary tra... [+11]

Status: Not yet recruiting

Study of NM8074 in Patients With aHUS With Evidence of Ongoing Thrombotic Microangiopathy

This is a Phase II, open-label study designed to determine if intravenously administered NM8074 results in remission from TMA in treatment-naïve aHUS patients.

Participants needed: 12
Trial details
Phase: Phase 2Age: 18-65Biological sex: AllType: InterventionalSponsor: NovelMed TherapeuticsUpdated: Apr 13, 2026
Eligibility criteria

Patients ≥ 18 years at the time of consent [+10]

History of bone marrow, hematopoietic stem cell, or solid organ transplantation [+14]

Status: Not yet recruiting

Study of NM8074 in Adult PNH Patients With Inadequate Response to Soliris

This is a Phase II, open-label study designed to evaluate the safety, efficacy, and immunogenicity of NM8074 in PNH patients undergoing complement-inhibitor therapy with Soliris.

Participants needed: 12
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: NovelMed TherapeuticsUpdated: Apr 13, 2026
Eligibility criteria

Patients ≥ 18 years (males and females), weight ≥ 45 kg at the time of consent. [+8]

Subjects currently or previously under other complement inhibitor treatments oth... [+13]

Status: Not yet recruiting

Study of NM8074 in Adult C3 Glomerulopathy Patients

This is a Phase Ib, open-label, dose-escalation study designed to evaluate the safety, efficacy, and immunogenicity of NM8074 administered intravenously to patients with C3 Glomerulopathy.

Participants needed: 18
Trial details
Phase: Phase 1, Phase 2Age: 18-65Biological sex: AllType: InterventionalSponsor: NovelMed TherapeuticsUpdated: Apr 13, 2026
Eligibility criteria

Patients ≥ 18 and ≤ 65 years at the time of consent [+8]

Use of other investigational drugs at the time of enrollment [+10]

Status: Not yet recruiting

Study of NM8074 in Soliris-Treated Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

The proposed study, NM8074-PNH-101, is a phase II, open-label, multi-dose, unicenter trial to evaluate the safety and efficacy of NM8074 in Soliris-treated PNH subjects.

Participants needed: 6
Trial details
Phase: Phase 2Age: 18-65Biological sex: AllType: InterventionalSponsor: NovelMed TherapeuticsUpdated: Mar 30, 2025
Eligibility criteria

Male or female patients ≥ 18 years at the time of consent [+7]

Platelet count < 30,000/µL at Screening [+19]

Status: Not yet recruiting

Study of NM8074 in Patients with Dermatomyositis (DM)

This is a Phase II, open-label, multicenter study to evaluate the safety and efficacy of NM8074 administered via intravenous infusion in patients with Dermatomyositis (DM).

Participants needed: 8
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: NovelMed TherapeuticsUpdated: Mar 25, 2025
Eligibility criteria

Male and female patients ≥18 years of age at the time of consent. [+5]

Subjects with drug-induced myositis [+10]

Status: Not yet recruiting

Study of NM8074 in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis (AAV)

This is a Randomized, Double-Blind, Placebo-Controlled Study designed to assess safety, tolerability, and efficacy of NM8074 in AAV patients when used in combination with Standard of Care (SOC) cyclophosphamide/azathioprine or rituximab plus corticosteroids.

Participants needed: 12
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: NovelMed TherapeuticsUpdated: Mar 11, 2025
Eligibility criteria

Clinical diagnosis of granulomatosis with polyangiitis (GPA), microscopic polyan... [+8]

Severe disease as determined by alveolar hemorrhage, hemoptysis, rapid onset mon... [+17]

Status: Not yet recruiting

Study of Efficacy and Safety of NM8074 in Adult PNH Patients Who Are Naive to Complement Inhibitor Therapy

This is a Phase II, open-label study designed to evaluate the safety, efficacy, and immunogenicity of NM8074 administered intravenously to adult patients with Paroxysmal Nocturnal Hemoglobinuria (PNH).

Participants needed: 12
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: NovelMed TherapeuticsUpdated: Mar 11, 2025
Eligibility criteria

Patients ≥ 18 years (males and females), weight ≥ 45 kg at the time of consent [+7]

History of bone marrow, hematopoietic stem cell, or solid organ transplantation [+14]