Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study of OT-101 With mFOLFIRINOX in Patients With Advanced and Unresectable or Metastatic Pancreatic Cancer

The goal of this clinical study is to compare the efficacy and safety of OT-101 in combination with mFOLFIRINOX (folinic acid, 5-FU, irinotecan, oxaliplatin) to mFOLFIRINOX alone in patients with advanced and unresectable or metastatic pancreatic cancer.

Participants needed: 455
Trial details
Phase: Phase 2, Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Oncotelic Inc.Updated: Aug 13, 2024Locations: 2
Eligibility criteria

Histopathology from primary tumor in pancreas, OR [+18]

Diagnosis of pancreatic islet neoplasm, acinar cell carcinoma, non-adenocarcinom... [+30]

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Status: Not yet recruiting

OT-101 in Combination With Pembrolizumab in Subjects With Malignant Pleural Mesothelioma Failing to Respond to Checkpoint Inhibition

This is a study of OT-101, a TGF-b2 inhibitor in combination of pembrolizumab in patients with malignant pleural mesothelioma. Both efficacy assessment, and safety and tolerability of various dose of OT-101 in combination of pembrolizumab are evaluated.

Participants needed: 63
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Oncotelic Inc.Updated: Mar 15, 2024Locations: 1
Eligibility criteria

Male/female participants who are at least 18 years of age on the day of signing... [+8]

A WOCBP who has a positive urine pregnancy test within 72 hours prior to agent a... [+17]

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