Status: Recruiting
Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children
The MATIC-2 is a multicenter clinical trial enrolling children who are less than 18 years of age with hemorrhagic shock potentially needing significant blood transfusion. The primary objective of the clinical trial is to determine the effectiveness of Low Titer Group O Whole Blood (LTOWB) compared to component therapy (CT), and Tranexamic Acid (TXA) compared to placebo in decreasing 24-hour all-cause mortality in children with traumatic life threatening hemorrhage.
Participants needed: 1,000
Trial details
Phase: Phase 3Age: Up to 17Biological sex: AllType: InterventionalSponsor: Philip SpinellaUpdated: May 11, 2026Locations: 23
Eligibility criteria
Children, defined as less than estimated18 years of age with traumatic injury [+4]
Patient with devastating traumatic brain injury not expected to survive due to m... [+12]