Clinical trials

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Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Monitoring Patients With Repetitive Head Impact With Gamma-glutamylcysteine Supplementation

The goal of this clinical trial is to test whether the gamma - glutamylcystiene (GGC) oral supplement can reach the brain and subsequently increase antioxidant glutathione (GSH) level in people with repetitive head impact (RHI). This will reduce the oxidative stress related injury in people with RHI.This unique study's main objective is to test the: 1. Change in GSH in brain and blood levels through GGC supplementation. 2. Change in the cognitive function in RHI patients due to GGC supplementation.

Participants needed: 30
Trial details
Phase: Phase 1Age: 30-70Biological sex: AllType: InterventionalSponsor: Pravat MandalUpdated: Jun 3, 2026Locations: 1
Eligibility criteria

Retired NFL player, retired Navy SEAL/army personnel with combat experience expo... [+3]

Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, m... [+8]

Status: Recruiting

Safety And Tolerability Of Gamma Glutamylcysteine (GGC) Oral Supplementation In MCI Patients

The goal of this study is to evaluate the safety and tolerability of Gamma Glutamylcysteine (GGC) supplement at different doses (400mg/day or 800mg/day or 1200mg/day) when administered orally to patients with MCI over 3 months. This study is designed to generate preliminary clinical safety data to inform the feasibility and design of larger controlled trials.

Participants needed: 9
Trial details
Phase: Phase 1Age: 55-80Biological sex: AllType: InterventionalSponsor: Pravat MandalUpdated: Jun 3, 2026Locations: 1
Eligibility criteria

Memory complaints; [+4]

Subjects with acute head trauma or head injury involving loss of consciousness; [+4]

Status: Recruiting

Enrichment of Glutathione Using Gamma-glutamylcysteine Supplementation in Parkinson's Disease Patients.

This study is designed l to evaluate the effects of GGC oral supplementation in early Parkinson's disease (PD) patients. The main objectives of the study are to evaluate: 1. To study the enrichment of master antioxidant, glutathione (GSH) levels in brain and blood of these PD patients compared to baseline due to GGC supplementation. 2. To study the changes in motor function, cognitive skills in PD patients due to GGC oral supplementation 3. To study impact of GGC on gut health on the PD patients.

Participants needed: 12
Trial details
Phase: Phase 1Age: 50-80Biological sex: AllType: InterventionalSponsor: Pravat MandalUpdated: May 4, 2026Locations: 1
Eligibility criteria

Confirmed Parkinson's Disease diagnosis. [+3]

Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, m... [+7]