Health Trials

Clinical trials

7

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety

A Multi-Center, Single-Arm Clinical Trial to Investigate the Efficacy and Safety of Elsunersen in Pediatric Participants with Early Onset SCN2A Developmental and Epileptic Encephalopathy

Participants needed: 40
Trial details
Phase: Phase 3Age: 1-18Biological sex: AllType: InterventionalSponsor: Praxis Precision MedicinesUpdated: May 27, 2026Locations: 10
Eligibility criteria

Has a documented Gain of Function SCN2A variant confirmed through genetic testin... [+2]

Has any clinically significant or known pathogenic genetic variant other than in... [+3]

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Status: Recruiting

A Clinical Trial for Participants With DEE to Assess Efficacy, Safety, Tolerability, and PK of Relutrigine

A Phase 3, Randomized, Multi-Center, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Relutrigine in Participants with Developmental and Epileptic Encephalopathies Followed by an Open-Label Extension

Participants needed: 160
Trial details
Phase: Phase 3Age: 2-65Biological sex: AllType: InterventionalSponsor: Praxis Precision MedicinesUpdated: May 11, 2026Locations: 11
Eligibility criteria

Has a documented diagnosis of a developmental and epileptic encephalopathy. [+2]

Has a history of left bundle branch block, arrhythmias, Brugada syndrome, congen... [+5]

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Status: Recruiting

Double-blind, Randomized Clinical Trial Evaluating the Efficacy and Safety of Vormatrigine in Adults With Focal Seizures

A multicenter, double-blind, randomized, placebo-controlled clinical trial to evaluate the efficacy and safety of vormatrigine in adults with focal seizures (POWER2)

Participants needed: 300
Trial details
Phase: Phase 3Age: 18-85Biological sex: AllType: InterventionalSponsor: Praxis Precision MedicinesUpdated: Apr 1, 2026Locations: 7
Eligibility criteria

Has a diagnosis of focal onset epilepsy according to the International League Ag... [+4]

evidence of experiencing pseudo or psychogenic seizures [+22]

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Status: Recruiting

A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy

The goal of this trial is to learn about the effect of PRAX-222 in pediatric participants with early onset SCN2A developmental and epileptic encephalopathy (DEE), aged 2 to 18 years.

Participants needed: 60
Trial details
Phase: Phase 1, Phase 2Age: 2-18Biological sex: AllType: InterventionalSponsor: Praxis Precision MedicinesUpdated: Aug 21, 2025Locations: 3
Eligibility criteria

Has onset of seizures prior to 3 months of age. [+3]

Has any clinically significant or known pathogenic genetic variant other than in... [+2]

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Status: Recruiting

Double-blind, Randomized Trial of PRAX-628 in Adults With Focal Seizures to Evaluate Efficacy and Safety (POWER1)

A Double-Blind, Randomized, Multicenter, Trial Evaluating the Efficacy and Safety of PRAX-628 in Adults With Focal Seizures (POWER1)

Participants needed: 230
Trial details
Phase: Phase 2, Phase 3Age: 18-75Biological sex: AllType: InterventionalSponsor: Praxis Precision MedicinesUpdated: May 31, 2025Locations: 26
Eligibility criteria

A diagnosis of focal onset epilepsy according to the International League Agains... [+1]

Subject has had any of the of the following within the 12-month period preceding... [+8]

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Status: Recruiting

An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures

An Open Label Clinical Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adult Patients With Focal Onset or Primary Generalized Tonic-Clonic Seizures

Participants needed: 50
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Praxis Precision MedicinesUpdated: Apr 3, 2025Locations: 11
Eligibility criteria

A diagnosis of focal onset seizures or idiopathic generalized tonic clonic seizu... [+3]

History of pseudo or psychogenic seizures, or cluster seizures only, within the... [+10]

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Status: Not yet recruiting

A Clinical Trial to Evaluate the Relative Bioavailability of PRAX-628

A phase I clinical trial to evaluate the relative bioavailability of PRAX-628 tablet formulation compared to capsule formulation

Participants needed: 16
Trial details
Phase: Phase 1Age: 18-55Biological sex: AllType: InterventionalSponsor: Praxis Precision MedicinesUpdated: Feb 21, 2025Locations: 1
Eligibility criteria

Weight of at least 50 kg with body mass index (BMI) between 18 and 32 kg/m2 [+4]

Any clinically significant abnormalities, medical, or psychiatric conditions ide... [+16]

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