Health Trials

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

PBGENE-DMD Phase 1/2a Safety and Preliminary Efficacy Study in Duchenne Muscular Dystrophy (FUNCTION-DMD)

The purpose of this Phase 1/2a trial is to evaluate the safety, tolerability, and preliminary efficacy of PBGENE-DMD in patients with DMD harboring mutations amenable to excision of exons 45-55. Given the limitations of existing therapeutic strategies, PBGENE-DMD represents a novel, innovative approach with the potential for a one-time, durable correction of the underlying genetic defect in the largest molecular subset of patients with DMD.

Participants needed: 18
Trial details
Phase: Phase 1, Phase 2Age: 2-7Biological sex: MaleType: InterventionalSponsor: Precision BioSciences, Inc.Updated: Jun 23, 2026Locations: 2
Eligibility criteria

Males, 2 to 7 years of age, inclusive, at the time of informed consent/assent [+10]

Prior treatment with any gene therapy, gene editing therapy, or cell-based thera... [+8]

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Status: Recruiting

Phase 1 Study to Evaluate Safety and Antiviral Activity of PBGENE-HBV in Adult Patients With Chronic Hepatitis B

This is a Phase 1, open-label, dose escalation and dose expansion study to evaluate the safety, tolerability, PK, and antiviral activity of PBGENE-HBV in adult participants with chronic hepatitis B.

Participants needed: 45
Trial details
Phase: Phase 1Age: 18-70Biological sex: AllType: InterventionalSponsor: Precision BioSciences, Inc.Updated: Sep 26, 2025Locations: 4
Eligibility criteria

Male or women of non-child bearing potential [+5]

No history of cirrhosis of the liver [+5]

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